他莫西芬-十一酸睾酮联合治疗严重少(弱)精子症、分泌型无精子症.pdfVIP

426 J Mod Urol. Vo l. 16 No.5 Sep.2011 ·抢 着· 文章编号，1009-8291(2011)05号0426-03 他莫西芬-十一酸辜嗣联合治疗严重少(弱)椅子症、分泌型无椅子症 宋博，蔡志明 〈北京大学深圳医院广东省男性生殖与遗传重点实验室，广东深圳 518036) Efficacy of combined testosterone undecanoate with tamoxifen citratein treatment for spermatogenic arrest SONG Bo. CAI Zhi-ming (Guangdong Key Lab. Male Reproductive Medicine Genetics , Shenzhen Hospital , Peking University , Shenzhen 518036 , China) ABSTRACT: Objective To evaluate the efficacy of combioed tamoxifen citrate and T undecanoate treatment 00 seminal paramete四 in patients with spermatogenic arr臼t. Methods Data of 4: patíents with azoopermatism and 8 patients with oligospermatism who were treated in the outpatient department were reviewed. T undecanoate (40 mg two or thr回 times per day) and tamoxifen citrate (10 mg two times p盯 day) were administered. Results Tamoxifen citrate pl田 T undecanoate treatment produced a satisfactory improvement of total sperm number and motility after 2 and 3 田onths. Fo Uicle.stimulating hormone (FSH) and luteinizing hormooe (LH) 皿 serum increased after treatment. Conclusion The combination of tamoxifen citrate with T undecanoate could significantly 皿prove sperm COUnt , which could serve 田 a treatment for P町matogenic arrest. KEY WORDS: spermatogenic arrest; azoopeImatism; oligozoospermia; testosterone; tamoxifen citrate 摘要z 晴筒 结合近来的文献报道以及临床材料，探讨生精障碍的药物治疗方案，李晶 12 例坐精阻滞患者中分泌型元精子症 4 例，严重少(弱)精子症 8 例.采用他莫西芬，十一酸事嗣联合泊疗.时间 1-3 月. ，串串 治疗前后比较.患者精液体棋无统计 学差异，精子密度(少帽子症〉或精于数量(无精子症)具有统计学意义s 血清 FSH、 LHT 泊疗后水平较治疗前提高，事嗣浓度无统 计学差异. LSD-，检验显示，少椅子症患者中，治疗后 2 月精于密度较治疗前明显提高(P=O.018) 呻级椅子比例在治疗后 1 月 (P=O.OIλ治疗后 2 月 (P=0.02)较治疗前明显升高。，在串他莫西芬-十 酸辜酬联合应用，能提高精于数量，可以来用他莫 西芬-十一醒辜商联合治疗精于发生障碍. 关键词:生精回滞，无精于症$少((弱)精子症s 皇回g 他莫西芬 中固分提号，R697 文献标志码:A 目前对于男性分泌型元精子症、严重少(弱)精子