丹参素保护心血管系统药理作用机制研究进展_王冰瑶.pdfVIP

Chinese Traditional and Herbal Drugs 45 17 2014 9 2571 * 300193 - - R285 A 0253 - 2670(2014)17 - 2571 - 05 DOI: 10.7501/j.issn.0253-2670.2014.17.027 Pharmacologic mechanism for protective effects of danshensu on cardiovascular system WANG Bing-yao, WU Xiao-yan, FAN Guan-wei State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China Abstract: Cardiovascular disease is becoming the leading cause of death in the world. Salvia miltiorrhiza has a history of thousands of years in clinical therapy in China, which is widely used in the treatment of coronary heart disease, myocardial infarction, blood circulation diseases, and other cardiovascular diseases. More and more studies show that danshensu, the main water-soluble component in S. miltiorrhiza, has a variety of pharmacological effects, including inflammation and tumor inhibition, neuro and myocardial protection, immunity improving, and so on. With further research, the mechanisms of these pharmacological effects have been gradually clear. In this paper, we focus on the mechanism of danshensu on cardiovascular protection and provide a theoretical basis for the further study and clinical application of danshensu. The aspects of mechanism include inhibition on ischemia/reperfusion injury, hypertension, myocardial infarction, atherosclerosis, high cholesterol, and hypertension, protection of endothelial cells, and so on. Key words: danshensu; cardiovascular; ischemia reperfusion injury; myocardial infarction; atherosclerosis