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Role of Genetic Polymorphismsin Responses to Toxic Agents;“Toxicology is concerned with the interaction between xenobiotics and biological molecules directly or indirectly coded in the DNA, and can be regarded as a branch of GENETICS.” Michael F.W. Festing (2001);TERMINOLOGY Gene: A sequence of DNA bases that encodes a protein Allele: A sequence of DNA bases Locus: Physical location of an allele on a chromosome Linkage: Proximity of two alleles on a chromosome Marker: An allele of known position on a chromosome Distance: Number of base-pairs between two alleles centiMorgan: Probabilistic dist