普罗布考与普伐他汀预防经皮冠状动脉介入治疗后再狭窄的对比研究_王敬萍.pdf

2009 10 17 5　ChinJInterventCardio,lOctober2009, Vol17, No.5 ·25 1· ·· 王敬萍　安健　张悟棠　王日军　雷新宇　王仲朝　张晓娟　王慧仙　芦丽芳　李保 【】　　 (PCI)。　 PCI 82 (n=4 2) (n=40 )。 4 1 000 mg/d 4 0 mg/d。 4 。 24 。, 24 。　 PCI 24 , ( ) (P0.05 )。(22.5%) (36.8%, P0.05 ), ( 23.25% ±10.08% 0.25 ±0.41) ( 34.76%±16.99% 0.42 ±0.6 8, P0.05 ), (2.11± 1.02 mm) (1.51±0.96 mm, P0.05 )。 (P0.05 )。　PCI4 PCI。 【】　, , ;　;　;　 do:i10.3969/.jissn.1004-88 12.2009.05.003 Probucolandpravastatininthepreventionofrestenosisafterpercutaneouscoronaryintervention　 WANGJingping, ANJian, ZHANGWutang, eta.lDeparmtentofCardiovascularInterventionCente,rShanxi ProvincialCardiovascularHospita,lTaiyuan0 30024, China Correspondingautho:rLIBao, Emai:lxyslibao@ 【Abstract】　Objective　Toevaluatetheefficacyofprobucolincomparisonwithpravastatininthe preventionofrestenosisinpatientswithPCI.Methods　Atotalof82 patientswithstableanginapectoris wererandomlyassignedtoeither1000 mg/dofprobucol(n=42 )or40 mg/dofpravastatin(n=40 ) therapyfor4 weeksbeforePC.IAfter4 weeksofpremedication, thetwogroupsunderwentbaremetalstent (BMS)implantation.Probucolandpravastatinwerecontinueduntilfollow-upangiographyperformedat24 weeksafterPC.IAfterdischarg,emonthlyclinicalfollow-upandangiographicfollow-upat24 weekswere performed.Results　Bytheendofthe24-week-follow-up, comparisonofclinicalendpoints(death, AM,I strokeandemergencyrevascularization)betweenthetwogroupsshowednostatisticaldifferences(P 0.05 ).Repeatangiographyperformed24 weeksafterPC,Ishowedthattherestenosisratewas22.5% inthe probucolgroupand36.8% inthepravastatingroup(P0.05 ).Thepercentageofdiameterstenosis (2 3.25% ±10.0 8% vs34.76%±16.99%, P0.05 )andthelatelossindex(0.25 ±0.4 1 vs0.4 2 ± 0.68, P0.05)intheprobucolgroupweresignificantlylowerthanthoseinthepravastatingroup.Netgain intheprobucolgroupwasgreaterthanthatinthepravastatingroup(2.11±1.02 mmvs1