探析白细胞介素(国外英文资料).docVIP

探析白细胞介素(国外英文资料) Interleukin? The regulation of immune cells Abstract: IL?? In the course of biological activity, with IL? 2, IL?? 4, IL?? 7, IL?? 9 and IL?? The cytokine receptors share the gamma-chain [1], which are members of the family of the dependent cytokines of the gammas. In recent years, the study of IL? 21 have a deep understanding of biological activity, it can widely to adjust T cells, B cells, NK cells and the function of bone marrow cells, in autoimmune diseases, allergic diseases and antitumor immunity plays an important role, so it has potential clinical value. The main review in this article is IL? 21 for three immune cells called T, B and NK cells biological regulation, to understand its role in the process of disease and provide guidance for the biological treatment of disease in the future. ? Keywords: interleukin 21 immuno-mediated B cell NK cell T cells ? 1? IL?? 21 and its receptor 1.1? IL?? 21? IL mature man?? The relative molecular mass of 21 (Mr) is 15,000, with 131 amino acids forming a four-helical beam structure domain and IL? 2, IL?? 4 and IL?? The structure is homologous. IL?? 21 genes and IL?? 2 and IL?? The 15 genes are located in the same chromatin region, located in 4q26? Q27, with IL? The gene is only about 180 KB apart. The arm papers network IL?? The 21 is mainly derived from the active CD4 + T cell [2]. Wurster and other [3] observations, the C57BL / 6 rat T helper cells that were initially stimulated in Th1, or Th2, were used to express the microexpression of IL? Once differentiated into Th2 cells, the stable expression of IL? The 21 cytokines are not affected by IL? 4 and IFN? Dial the mei female fan? But there is no IL in the Th1 cell. The transcription of 21mRNA, so they think IL? 21 is a type of Th2 cytokines. Coquet et al. [4] recently discovered the use of anti?? CD3 / CD28 CD1d restrictive sheath glycolipid antigens (capture zhangs Yu has grown two millimeters possess.you alpha? Food? Amide) stimulation of NKT cells of