细胞视黄酸结合蛋白与肿瘤相关研究.pdf(国外英文资料).docVIP

细胞视黄酸结合蛋白与肿瘤相关研究.pdf(国外英文资料) , 68, Chemistry of life, 31, 2011 Low Mini Review CHEMISTRY OF LIFE 2011,31 (1) Article number: 1000-1336 (2011) 1-0068-04 The cell retinoic acid binding protein and tumor research Yang Fang The college of agriculture and life sciences, ankang 725,000 Abstract: cytoplasmic acid binding protein (CRABP) was used to interact with the nucleotropic receptor on cytoplasmic acid and nucleus, while promoting retinoic acid Metabolic enzyme activity, enhanced the conversion rate of retinoic acid. CRABP contains two highly homologous proteins in vertebrate cells: CRABP1 and CRABP2. CRABP is a protein with low molecular weight and is highly conservative. Existing studies have shown that in many tumors... CRABP genetic abnormalities Gene expression levels are different from normal tissue; ... The abnormal methylation of the CRABP was associated with low survival rates in some tumours, CRABP Because it can be a common target for tumor diagnosis and prognosis. Keywords: retinoic acid binding protein; Methylation. Tumor; Molecular targets Middle image classification number: Q75 Retinoic acid (RA) is A vitamin A (retinol) Derivatives, the ligand of the important nuclear receptor family, are present The most important of the inductive agents found, for various organizations, Cells have a strong induced differentiation and are widely used in tumors Chemical treatment. The chemical properties of retinoic acid are not stable and fat Solubility, therefore, must be in the process of absorption, transport, and secretion Special proteins combined. Its physiological functions are mainly composed of two types of proteins Qualitative mediated, namely: retinoic acid receptor and retinoic acid binding protein. retinoic The retinoic acid receptor (RAR) includes RAR a, RARb, and... RARg and retinoic acid X receptors. B, g. Cellular retinoic acid - binding Protein, CRABP, is a cytoplasmic medium retinoic acid molecule and nucleus The important substances that interact w