自体骨髓干细胞移植疗法治疗106例下肢严重缺血患者的临床疗效分析.pdfVIP

海南医学院学报 2013 , 19(3) }ournalof Hainan Medical University 365 网络出版地址:/kcms/detail/46.1049. R.1726.006. html 自体骨髓干细胞移植疗法治疗 106 例下肢严重缺血患者的临床疗效分 析 胡长付 (广西省桂林医学院附属医院血管乳腺外科，广西桂林 541002) [摘要]句简:探讨自体骨髓千细胞移植治疗下肢严重缺血患者的临床疗效。方传:对我院 2009 年 2 月 ~2012 年 3 月收治的 106 例下肢严重缺血患者，从榕骨处抽取自体骨髓血，分离出单个核细胞，再制成 细胞悬液。通过股动脉插管，在球囊阻断动脉血流的情况下将千细胞悬液注射到缺血的下肢动脉。结 果:治疗后患者的疼痛明显减轻，与治疗前相比差异具有统计学意义(MH=95 ， P0.05); 治疗后冷感 许分明显低于治疗前(PO. 05); 而且皮行距离、琛成指数、经皮氧分压均较治疗前明显增加(PO.O日。 所有患者术后随访 8 个月，未见明显不良反应发生。结抢:自体骨髓千细胞移植是治疗下肢严重缺血的 一种简单、安全、有效的手段，值得临床广泛推广和应用。 [关键词]自体骨髓千细胞;移植疗法p 下肢严重缺血 [中固分类号] R457. 7 [文献标识码] A [文章编号] 1007-1237(2013)03-0365-02 Clinical efficacy of autologous bone marrow stem cell transplantation therapy for 106 pa- tients with severe lower limb Hu Chang-Fu (Deρartment of Vascular Breast Surgery , Affiliated Hospital of Guilin Medical College , Guilin 541002 China) [Fow由tion Project]: 7his 胁k is Financ切Ily suρ阳时by~挥妇1 Ft.仰仇tionfor αinical Studies乒um Commit阳of 岛创ical ] 0U17KÚ 0f 仙也蛇口四时sities (11221白白) [Author]:HUChang-fu (1 976-) , Male , Guilin , MD , PhD , Tel:,E-mail: huchangfu _t rw@ 126. com. Received: 2013-01-06 Revised: 2013-01-24 ]HMC ,2013;19(3):0365-0366 View from specialist: It is creative , and of certain scientific and educational value. [ABSTRACT] Objective: To investigate the clinical efficacy of autologous bone marrow stem cell transplantation for lower limb ischemia patients. Methods: Iliac blood of autologous bone marrow mono- nuclear cells were isolated from 106 severe lower limb ischemia patients that were admitted to our hospital from February 2009 to March 2012 , then made a