蛋白质组学在白假丝酵母研究中的应用.pdfVIP

l 上海交通大学学报(医学版) VoI.36 NO.12 Dec.2016 1804 I I JOURNAL OF SHANGHAI JIAO TONG UNIVERSITY (MEDICAL SCIENCE) 综述 蛋白质组学在自假丝酵母研究中的应用 刘锦燕\史册2 ，王影2 ，李文静2 ，赵悦2 ，朱巍巍1 ，项明洁 1 ， 2 l 上海交通大学医学院附属瑞金医院卢湾分院放免检验科，上海 200020 ， 2 上海交通大学医学院附属瑞金医院检验科，上海 200025 [摘要]白假丝酵母 (C.albicans) 是人类最常见的条件性致病真菌，其引起的侵袭性 C.albicans 病是导致日益增多的免疫功能低下患者 发病和死亡的原因之一。目前，临床抗真菌药物种类有限，耐药现象增多，新药物研发迸展缓慢，导致临床治疗压力极大。近期发展 起来的蛋白质组学研究提供了有效的新技术平台，已应用于 C.albicans 的致病因子、耐药机制、免疫应答和抗真菌药物作用机制研究 等方面。该文对近年来蛋白质组学技术新发展及应用于 C.albicans 相关研究进展作一综述。 [关键词]蛋白质组学g 生物质谱;臼假丝酵母 [001] I0 .3969!j.issn.1674-8115.2016.12.025 [中图分类号] R379 .4 [文献标志码 ]A Application of proteomics to the study on Candida albicans LlU Jin-yan SHI Ce ,WANG Ying , LI Wen才ing， ZHAO Yue ,ZHU Wei-wei ,XIANG Ming-jie 1.Department 01Laboratory Medici肘， Ruijin H。再， :pital Luwan Branch , Shanghai Jiao Tong Universi砂 Schoo/ 01Medicine , Shanghai 20002矶 China; 2.Department 01 Laboratory Medici肘， Ruijin Hospita/, Shanghai Jiao Tong University School 01Medici肘， Shanghai 200025, China [Abstract] Candida albicans (Calbicans) is the most common opportunistic human fungal pa由ogen causing invasive candidiasis , which is one of factors resulting in increasing morbidity and mortality in immunocompromised patients. Currently, limited types of antifungal drugs for clinical application, increased drug resistance , and slow progress of new drug development lead to more and more challenges in clinical treatment. Recently developed proteomics can provide a novel effective technology platform and has been applied to the study of Calbicans, including pathogenic factors , resistance mechanism , immune response , action mechanism of antifungal drugs,etc. In this paper, new development of proteomic technology and its application to