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2009-Enhancement of hepatic docosahexaenoic acid and arachidonic=FX=积累PUFA
Fish Sci (2009) 75:261–263
DOI 10.1007/s12562-008-0018-4
SHORT PAPER
Enhancement of hepatic docosahexaenoic acid and arachidonic
acid contents in C57BL/6J mice by dietary fucoxanthin
Takayuki Tsukui Æ Nobuko Baba Æ Masashi Hosokawa Æ
Tokutake Sashima Æ Kazuo Miyashita
Received: 12 May 2008 / Accepted: 10 July 2008 / Published online: 19 December 2008
The Japanese Society of Fisheries Science 2008
Keywords Amarouciaxanthin A Arachidonic acid [7]. Because the liver plays an important role in lipid
C57BL/6J Docosahexaenoic acid Fucoxanthin metabolism, an increase in hepatic DHA by fucoxanthin is
Fucoxanthinol Liver expected to show beneficial health effects. However,
KK-Ay mouse strain used in our previous study was a
genetically modified model for obesity/diabetes syndrome
The n-3 highly unsaturated fatty acids (HUFAs), such as y
due to its A /? genotype and young, 4-week age. In this
docosahexaenoic acid (DHA) and eicosapentaenoic acid study, we therefore examined the effect of fucoxanthin on
(EPA), are known to possess beneficial health properties the level of HUFAs in the liver using normal adult mice,
such as reduction of serum triacylglycerol and cholesterol namely C57BL/6J mice (male, 19 weeks old prior to
[1], anti-inflammatory [2], and anticancer effects [3]. In fucoxanthin feeding).
addition, DHA has been reported to be essential for brain Lipids were extracted from commercially available dry
function [4] and development, especially in babies and wakame (U. pin
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