药理学(中英课件).pdfVIP

Chapter 1 Chapter 1 Pharmacodynamics Pharmacodynamics 药物效应动力学 药物效应动力学  Pharmacological Action - Overview  Pharmacological Action - Overview  Dose-effect relationship  Dose-effect relationship  Mechanisms of drug actions  Mechanisms of drug actions  Drug receptors  Drug receptors 1- Pharmacological Action - Overview 1- Pharmacological Action - Overview 1.1 Action and effect of drug 1.1 Action and effect of drug Action Action  Specifically primary action between drug and cells or molecules Effect Effect Apparent functional and morphological changes induced by drug directly and/or indirectly 1- Pharmacological Action - Overview 1- Pharmacological Action - Overview 1.2 Direct and indirect effects of drugs 1.2 Direct and indirect effects of drugs Direct effects: Direct effects: Effects resulted from the action of drug on the target organ(s) or tissue(s) Indirect effects: Indirect effects: Effects resulted from functional integration of target system(s) and modulation system(s) BP ↑ direct BP direct Action on Action on vascular  vascular  HR ↓ indirect 1 HR indirect 1 receptors receptors Neuroendocrine Neuroendocrine modulation modulation Action Act