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O r i g i n a l P a p e r Abdominal Obesity Is Associated With Potassium Depletion and Changes in Glucose Homeostasis During Diuretic Therapy Lydia Sebba Souza Mariosa, MD, PhD; Fernando Flexa Ribeiro-Filho, MD, PhD; Marcelo Costa Batista, MD, PhD; Andréa Harumi Hirota, MD; Rodolfo Leão Borges, MD; Artur Beltrame Ribeiro, MD, PhD; Maria Teresa Zanella, MD, PhD The activation of the renin-angiotensin system bdominal obesity and arterial hypertension are (RAS) is an important mechanism that contributes amajor components of the metabolic syndrome.1 to hypertension in obese individuals . Thiazide arterial hypertension was described as the most fre- diuretics also activate the RAS in response to quent diagnostic criterion of metabolic syndrome in volume contraction and can lead to a decrease in both sexes in an apparently healthy Japanese popu- serum potassium values and glucose metabolism lation.2 the association between obesity, especially abnormalities . To evaluate the impact of abdomi- abdominal obesity, and hypertension has been dem- nal obesity on potassium depletion and glucose onstrated by several studies.3,4 abdominal obesity is 5 homeostasis in hypertensive patients receiving thi- clinically measured by waist circumference, which azide therapy, the authors studied 329 hyperten- has been referred to as a hypertriglyceridemic waist sive patients without known diabetes or impaired due to its ability, in association with fasting trig- renal function . Patients were stratified into 2 lyceride levels, to identify individuals at increased m