人体平衡型核苷转运蛋白的结构及应用研究进展-中国细胞生物学学报.PDF

中国细胞生物学学报 Chinese Journal of Cell Biology 2016, 38(6): 736–743 DOI: 10.11844/cj cb.2016.06.0050 人体平衡型核苷转运蛋白的结构及应用研究进展 1 2 1* Mark Bartlam2 郝振宇 刘瑞华 王莹莹 1 ( 环境污染过程与基准教育部重点实验室, 天津市城市生态环境修复与污染防治重点实验室, 南开大学环境科学与工程学院, 天津300071; 2南开大学生命科学学院, 天津300071) 摘要 通过参与合成和转运核苷及其类似物, 人体中的平衡型核苷转运蛋白在生物体内参 与了细胞发育、能量代谢和信号转导等众多生理生化过程, 其研究对于癌症、病毒感染等相关疾 病的治疗有着极为重要的意义。该文综述了该类蛋白质在人体内的发现历程、分类、结构和作用 机制, 并对于其在一些疾病治疗和药物开发方面的前景进行了展望。 关键词 平衡型核苷转运蛋白; 核苷转运; 蛋白结构; 转运机制 Structure and Application of Human Equilibrative Nucleoside Transporter―A Review 1 2 1*, Mark Bartlam2 Hao Zhenyu , Liu Ruihua , Wang Yingying 1 ( Tianjin Key Laboratory of Environmental Remediation and Pollution Control, Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China ; 2 College of Life Sciences, Nankai University, Tiajin 300071, China) Abstract The equilibrative nucleoside transporters play critical roles in various biochemical and physiological process by regulating the synthesis and transport of nucleosides, such as cell growth, energy metabolism and signal transduction in human being. Meanwhile, the related studies are meaningful for the therapy of cancer and viral infection and other diseases. Here in this review, the recent research progresses of equilibrative nucleoside transporters, including history, classification, molecular structure and mechanism, were summarized and their potential applications in disease treatment and drug development were also disc