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换血治疗对52例重度高胆红素血症新生儿疗效探析
换血治疗对52例重度高胆红素血症新生儿的疗效分析 【摘要】 目的 分析换血治疗对重度高胆红素血症新生儿疗效。方法 52例重度高胆红素血症新生儿采用换血治疗(全自动动静脉同步换血法), 通过换血前、中、后血糖?p急诊八项?p胆红素各项指标变化, 分析换血治疗的疗效。结果 患儿换血前与换血中总胆红素、间接胆红素、血钾、血钠、血氯、总蛋白、血糖比较, 差异有统计学意义(P0.05)。换血前总胆红素、间接胆红素、总蛋白[(505.00±81.46)μmol/L、(473.71±72.87)μmol/L、(51.95±4.26)g/L]与换血后[(166.79±58.91)μmol/L、(154.86±58.13)μmol/L、(46.34±4.51)g/L]比较, 差异有统计学意义(P0.05)。患儿均治愈出院。结论 换血治疗对新生儿重度高胆红素血症疗效显著, 安全可靠, 见效快, 预后好
【关键词】 新生儿;高胆红素血症;换血治疗
DOI:10.14163/j.cnki.11-5547/r.2016.23.007
【Abstract】 Objective To analyze curative effect by blood exchange transfusion treatment for newborn with severe hyperbilirubinemia. Methods A total of 52 newborn with severe hyperbilirubinemia received blood exchange transfusion treatment (full-automatic arteriovenous synehronous exchange transfusion). Their curative effects were analyzed on the basis of changed indexes of blood glucose, emergency eight items and bilirubin before, during and after exchange. Results The differences of total bilirubin, indirect bilirubin, serum potassium, serum sodium, serum chlorine, total protein and blood glucose had statistical significance before and during blood exchange (P0.05). The difference of total bilirubin, indirect bilirubin, and total protein before exchange [(505.00±81.46)μmol/L、
(473.71±72.87)μmol/L、(51.95±4.26)g/L] and after exchange [(166.79±58.91)μmol/L、(154.86±58.13)μmol/L、
(46.34±4.51)g/L] had statistical significance (P0.05). All children were healed and discharged. Conclusion Blood exchange transfusion treatment shows remarkably curative effect for newborn with severe hyperbilirubinemia. This method is safe and creditable, along with quick effect and good prognosis.
【Key words】 Newborn; Hyperbilirubinemia; Blood exchange transfusion treatment
重度高胆红素血症是新生儿期的一种常见病, 主要是由于患儿降生后体内的红细胞破坏过度, 超出了肝脏清除胆红素的能力, 引起血液中胆红素水平显著提升, 可导致患儿听力障碍、脑瘫、智力发育迟缓, 甚至死亡。因此, 如何快速治疗重度高胆红素血症, 成为临床上广泛关注的问题[1]。在对重度高胆红素血症进行治疗时, 换血疗法是非常有效的方法之一, 溶血病通过换血疗法能快速换出致敏和抗体红细胞, 使血清胆红素降低, 溶血减轻, 对核黄疸进行有效预防, 而且还能对贫血进行纠正, 对心力衰竭进行预防[2]。本文
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