免疫预防与免疫治疗陈建忠.pptVIP

III. Cellular Immunotherapy 2. Adoptive immunotherapy TIL LAK（CIK） 3. Stem cell transplantation Bone marrow Peripheral blood Umbilical blood VI. Biological response modifier and immunosuppressive agent 1. Biological response modifier(BRM) A variety of agents that stimulate the immune response non-specifically are called biological response modifier. Microorganism products: BCG, corynebacterium parvum (CP), polysaccharide Synthetic molecules:polyI:C CK Hormones:Thymosin, Thymopoietin Immunosuppressive agents 1. Chemicals Glucocorticoids, cyclophosphamide, azothioprine, etc. Immunosuppressive agents 2. Microorganism products Cyclosporin, FK506, rapamycin Summary Classification of immunoprophylaxis and their biological materials Classification of immunotherapy and their biological materials Thank you for your support and cooperation in my teaching! Synthetic peptide vaccine Small antigens can be made synthetically. e.g. HBs vaccine Synthetic B-and T-cell epitopes can be combined in various ways to optimize the resulting immune response. Genetic engineering vaccine Recombinant antigen vaccine To clone the selected gene into a vector (yeast) →to culture→to purify the Ag from the culture supernatant→antigen Recombinant vector vaccine To insert the desired gene into a vector (vaccinia) which can then be injected into the patient, allowed to replicate, express the gene and produce large amounts of the antigen. DNA vaccine These are based on the discovery that when DNA encoding a chosen microbial protein is injected intramuscularly or intradermally, host cells can take up these artificial genes and express the foreign protein for several weeks. Depending on the protein expressed, this can induce specific humoral or cellular immunity, or both. Transgenic plant vaccine Genes encoding the protective immunogens are transduced into plant cells. Such as tomato, potato, and banana, etc. Reverse vaccinology for identification novel vacc