血栓与止血基础理论20130604.pptVIP

* As previously described, coagulation is normally initiated when vessel or tissue injury exposes circulating factor VIIa to tissue factor. Through this interaction, a tissue factor–factor VIIa complex is formed and can subsequently activate small amounts of factors IX and X, eventually resulting in limited quantities of thrombin. Tissue factor pathway inhibitor is a protein that mediates the feedback inhibition of the tissue factor–factor VIIa complex, resulting in decreased activation of both factor IX and X. Small amounts of factor Xa are required for TFPI to achieve its inhibition of fa