高能射线对腮腺功能的影响和机理初探.docVIP

高能射线对腮腺功能的影响及机理初探 刘英杰2 胡国清1郑艳2 郑有合2景琴2唐 曦1潘鲁1黄乔1刘佳其1 目的：初步探讨高能射线对腮腺功能的影响及其机理，为头颈部肿瘤放疗后口腔干燥治疗提供理论基础。方法：年满4月大梅杂交猪8头，4头双侧唾液腺造瘘，15MV-X线单侧腮腺照射，5Gy/次，3次/W，总量40Gy/8次/16d，为实验组；对侧未照射腮腺为自身对照组；2头单纯造瘘为阴性对照组；余下2头不做任何处理，为病理对照组。观察照射动物临床征象变化；每日记录唾液总量，采用SPSS11.0最小显著性差异（LSD）检验比较实验组、自身对照组、阴性对照组分泌量差异；2月后取腮腺病理学检查，比较4组腮腺显微结构变化。结果：照射猪饮食下降、进食期间频繁饮水；照射组于13±2d起分泌明显减少，LSD处理显示试验组、自身对照组、阴性对照组间两两比较均有显著差异。病理学检查显示，照射腮腺总体结构尚存，细胞排列轻度紊乱，细胞数目无明显减少，部分胞核增大，胞浆相对增加，凋亡细胞少见，有区域分布趋势，自身对照组与阴性对照组腺体结构无明显变化。结论：辐射对唾液分泌的影响除细胞凋亡原因外，可能尚有其它重要机制。 关键词： 高能射线 唾液分泌 影响 The investment of the effects of high energy Xray on the slivary function and the pilot study of its mechenism. LIU Yingjie, HU Guoqing, ZHENG youhe, et al. The department of tumour , The 152 hospital of PLA. Henan , 467000, China. Abstract: Objective To invest the effects of high energy Xray on the slivary function and its mechanism, aims to provide guidance for the treatment of xerostomia caused by salivary irradiation injury. Method Fistulization of salivary ducts was operated on both sides of the three among the 8 Damei Hybridization swine, which ages ranges from 4 to 5 months, 4 of the swines were administered radiation on half side salivary glands by 15 MV-X ray, 5Gy per time, 3 times a week, 8 times add up to 40Gy, as radiated group. The contralateral parotids were taken as self-control group; The other 2 swines were merely fistulated, as negative group; And 2 swines were taken no disposal, as pathological control group. Record the sialon amount each day continuously, The least significant difference (LSD) of SPSS 11.0 was used to show the difference of sialon amount. 2 months later, pathological examination was performed to the parotid glands of each swine. Result: The irradiated swine showed lower diet, drinking frequently while eating; 13?dh days from the beginning of irradiation, the irradiated parotid exhibits decreasing in secretion, while the contralateral parotid increasing a little; Pathological examination shows no much