2ME减弱博来霉素在雌激素缺乏大鼠中所导致的PAH与肺纤维化.docxVIP

2-METHOXYESTRADIOL ATTENUATES BLEOMYCIN-INDUCED PULMONARY HYPERTENSION AND FIBROSIS IN ESTROGEN-DEFICIENT RATS（2ME减弱博来霉素在雌激素缺乏大鼠中所导致的肺动脉高压和肺纤维化）Tofovic S P, Zhang X, Jackson E K, et al.?[J]. Vascular pharmacology, 2009, 51(2-3): 190.Abstract（摘要）Pulmonary hypertension (PH) is a common and life-threatening complication of pulmonary fibrosis.（肺动脉高压（PH）是一种常见和威胁生命的肺纤维化的并发症。） Estradiol (E2) is protective in experimental PH, and its non-estrogenic metabolite 2-methoxyestradiol (2ME) prevents the development and retards the progression of monocrotaline-induced PH in male and female rats.（雌激素能在试验性肺动脉高压