胚胎嗅鞘细胞移植治疗Friedreich共济失调：疗效分析与安全性评价.pdfVIP

中国组织工程研究与临床康复 第 12 卷 第 12 期 2008 –03 –18 出版 Journal of Clinical Rehabilitative Tissue Engineering Research March 18, 2008 Vol.12, No.12 临床医学 胚胎嗅鞘细胞移植治疗Friedreich共济失调：疗效分析及安全性评价* 郗海涛，黄红云，陈 琳，张 峰，刘彦铖，张 健 Embryonic olfactory ensheathing cell transplantation for treating Friedreich ataxia: An analysis of outcome and safety Xi Hai-tao, Huang Hong-yun, Chen Lin, Zhang Feng, Liu Yan-cheng, Zhang Jian Abstract: Between August 2005 and April 2007, six patients (one male and five females) with Friedreichs ataxia diagnosed by 1Beijing Hongtianji Geoffroy and arding standards and DNA were enrolled. Their ages ranged from 14 to 28 years. The duration of course was 5 to 14 Neuroscience Academy, Beijing years. All the patients signed the informed content and the clinical study was approved by Medical Ethics Committee. Olfactory 100041, China; 6 2 ensheathing cells (2 ×10 ) were transplanted into the diseased region of the spinal cord in 4 patients after general anesthesia and the Department of corona radiata of the parietal lobe in both sides in 2 patients. The neurological function was assessed before and 2 to 4 weeks after the Neurosurgery, Beijing Xishan surgery using International Cooperative Ataxia Rating Scale (ICARS) by World Federation of Neurology. The higher score presents Hospital and Beijing severe neurological functio