临床药师对重症监护室肝肾功能损害患者应用抗菌药物地干预.PDFVIP

临床药师对重症监护室肝肾功能损害患者应用抗菌药物的干预 研究 ＊ 陈文瑛 ，梁峰华，肖翔林，姜顺军，孟冬梅（广州医科大学附属第一医院，广州 510120） 中图分类号 R969.3；R978.1 文献标志码 A 文章编号 1001-0408（2014）18-1650-04 DOI 10.6039/j.issn. 1001-0408.2014.18.06 摘 要 目的：考察临床药师干预重症监护室（ICU ）肝肾功能损害患者应用抗菌药物的临床效果。方法：分别随机抽取我院 2009年6－12月（干预前）和2011年6－12月（干预后）入住ICU 的肝肾功能损害患者病历各100份，对抗菌药物用药频度（DDDs ） 和药物利用指数（DUI ）值、抗菌药物联合用药情况、抗菌药物用药合理性、死亡率等指标进行回顾性分析。结果：经临床药师干 2 预后，我院ICU 患者应用抗菌药物的合理性有明显的改善，合理率由67.83％上升至83.59％（χ ＝9.394，P ＝0.007＜0.05）。结论： 临床药师对ICU 肝肾功能损害患者应用抗菌药物的干预是可行并且有效的，对该类患者用药的安全、有效、合理、经济具有积极 的促进作用。 关键词 重症监护室；抗菌药物；肝功能损害；肾功能损害 Survey of Clinical Pharmacists Intervening in the Application of Antibiotics in ICU Patients with Liver and Kidney Dysfunction CHEN Wen-ying ，LIANG Feng-hua ，XIAO Xiang-lin ，JIANG Shun-jun ，MENG Dong-mei （The First Affiliated Hospital of Guangzhou Medical University ，Guangzhou 510120，China ） ABSTRACT OBJECTIVE ：To investigate the effect of clinical pharmacists intervening in the application of antibiotics in ICU pa- tients with liver and kidney dysfunction. METHODS ：The medical records of 100ICU patients with liver and kidney dysfunction in our hospital were randomly collected from Jun. to Dec. 2009（before intervention ）and from Jun. to Dec. 2011（after intervention ），re- spectively. The application of antibiotics was analyzed retrospectively in terms of DDDs ，DUI ，drug combination ，rationality of an- tibiotics use and mortality ，etc. RESULTS ：After the intervention of clinical pharmacist ，the rationality of antibiotics use in ICU pa- 2 tients was improved significantly ，raising from 67.83％to 83.59％ （χ ＝9.394，P ＝0.007＜0.05）. CONCLUSIONS ：It is effective and practicable for clinical pharmacists to intervene in the application of antibiotics in ICU patients with