新型噻吩-2-甲醛不对称双缩二氨基硫脲衍生物的合成及其抗菌活性.pdfVIP

学兔兔 2014年第22卷 合成化学 Vo1．22，2014 第3期，293～297 Chinese Joumal of Synthetic Chemistry No．3，293—297 · 研究论文· 新型噻吩-2．甲醛不对称双缩二氨基硫脲衍生物的 合成及其抗菌活性 仇丽颖，赵志刚，李 琳，张丽娜 (西南民族大学化学与环境保护工程学院，四川成都 610041) 摘要：1，3--氨基硫脲与芳香醛在冰醋酸催化下经缩合反应制得一系列单缩二氨基硫脲(3a一3k)；3a_3k分 别与噻吩-2．甲醛进一步缩合合成了11个新型的噻吩-2一甲醛不对称双缩二氨基硫脲类衍生物(Sa_5k)，其结 构经-H NMR，IR，ESI．Ms和元素分析表征。初步抗菌活性测定结果表明：部分目标化合物对枯草芽孢杆菌具 有抑菌活性；5d对金黄色葡萄球菌的Ic卯为4．29，优于对照药阿莫西林(1c5o 6．4)。 关 键 词：噻吩-2．甲醛；双缩二氨基硫脲；合成；抗菌活性 中图分类号：0625．7 文献标识码：A 文章编号：1005-1511(2014)03-0293-05 Synthesis and Antibacterial Activities of Novel Thiophene-2- formaldehyde Unsymmetrical Bisthiosemicarbazone Derivatives QIU Li-ying， ZHAO Zhi-gang，LI Lin， ZHANG Li—na (College of Chemistry and Environmental Protection Engineering， Southwest Umvemi~for Nationalities，Chengdu 610041，China) Abstract：Eleven novel unsymmetrical bis thiosemicarbazones(5a一5k)were synthesized by conden— safion of t}liophene-2一formMdehyde with a series of thiosemicarbazones．which were obtained by the reaction of thiocarbohydrazide with substituted aromatic Mdehydes using glacial acetic acid as the cat— alyst． I1Ie structures were characterized by H NMR，IR。ESI．MS and elemental analysis．Prelimina． ry antibacterial activities test indicated that some target compounds exhibit certain inhibitory activities against Bacillus subtilis．5d exhibit better inhibitory~ctivities than Amoxicillin against Staphylococcus Keywords：thiophene-2一formaldehyde；thiosemicarbazone