表面修饰可生物降解纳米载体的伊马替尼针对脑胶质瘤细胞系的调查：细胞内吸收和细胞毒性的研究.docxVIP

Investigation of imatinib loaded surface decorated biodegradablenanocarriers against glioblastoma cell lines:Intracellular uptake andcytotoxicity studies表面修饰可生物降解纳米载体的伊马替尼针对脑胶质瘤细胞系的调查：细胞内吸收和细胞毒性的研究A R S T R A C TOverexpression of P-glycoprotein (P-gp) efflux transporter in glioma cells thwarts the build-up oftherapeutic concentration of drugs usually resulting into poor therapeutic outcome. To surmountaforesaid challenge, Imatinib (IMM) loaded Poly-lactide-co-glycolic acid nanoparticles (IMM-PLGA-NPs)were developed and optimized by Box Behnken Design as a new treatment stratagem in malignantgl