第10章 肾上腺素受体激动药(国外英语资料).doc

第10章 肾上腺素受体激动药(国外英语资料) The tenth chapter is adrenergic receptor agonist Basic Requirements Key and difficult points Teaching hours Synopsis 1 basic requirements [TOP] 1.1 to master the classification of adrenergic agonists, pharmacological effects of various drugs, clinical applications and adverse reactions. 1.2 be familiar with the mechanism and process of adrenergic agonists. 2 key and difficult [TOP] 2.1 key Pharmacological actions and clinical applications of various drugs of adrenergic receptor agonists. 2.2 difficulties The mechanism and clinical application of adrenaline. 3 teaching hours [TOP] Recommendation 4 hours 4 Abstract [TOP], Section 1, section second, section third, section fourth 4.1. Structure-activity relationship and classification in the first section [TOP] [structure-activity relationship] The basic chemical structure of adrenergic agonists is beta benzene, which can be synthesized by various groups of adrenergic receptor agonists when the hydrogen and terminal amino groups of the benzene ring, alpha or beta carbon atoms are replaced by different groups. These groups can affect the affinity of drugs to alpha and beta receptors and the ability to activate receptors and affect the in vivo process of drugs. The difference of chemical groups on 1. benzene rings Hydrogen is substituted on the alpha carbon atom of the 2. alkane side chain 3. hydrogen atom is substituted on amino group 4. optical isomer [classification] According to the different adrenoceptor subtype selective and divided into three categories: the alpha adrenergic receptor agonists (-adrenoceptor, alpha agonists, alpha receptor agonist); alpha and beta adrenergic receptor agonists (agonists alpha, -adrenoceptor beta, alpha and beta agonists); beta adrenergic receptor agonists (3 -adrenoceptor agonists beta, beta receptor agonist) 4.2, second alpha adrenergic agonists, [TOP] Noradrenaline Medicinal NA is synthetic, unstable chemical properties, light, heat, easy to decompose, in n