BRCA1及乳腺癌的研究进展.PDFVIP

中国普外基础与临床杂志 2017年8月第24卷第8期 • 1 •   ·综 述· BRCA1 与乳腺癌的研究进展 1 2 查国松 ，左文述 1. 济南大学 山东省医学科学院医学与生命科学学院（济南  250000 ） 2. 山东省肿瘤医院外二科（济南  250000 ） 【摘要】   目的     了解乳腺癌 1 号（BRCA1 ）基因及其与乳腺癌发病的关系，并分析其在临床上对乳腺癌治疗 的影响。 方法    对有关 BRCA1 基因与乳腺癌关系研究的相关文献进行综述。 结果    BRCA1 基因是一种抑癌基 因，其突变而导致的结构发生变化和功能异常与乳腺癌的发生密切相关，其治疗效果也与BRCA1的表达情况或是 否突变有关。 结论    BRCA1 基因的突变与女性乳腺癌的发生和发展有密切关系，可根据 BRCA1 基因的表达情况 或突变特性来寻找对乳腺癌的综合治疗思路，对其进行进一步的深入研究有利于探索乳腺癌综合治疗的 金标准。 【关键词】  乳腺癌；BRCA1 基因；药物治疗；靶向治疗 Research progress of BRCA1 and breast cancer 1 2 ZHA Guosong , ZUO Wenshu 1. School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250000, P.R.China 2. The Second Department of Surgery, Shandong Tumor Hospital, Jinan 250000, P.R.China Corresponding author: ZUO Wenshu, Email: cjcptzws@126.com 【Abstract 】 Objective    To understand breast cancer 1 (BRCA1) gene and relationship between BRCA1 gene and breast cancer, and analyze its effect on clinical comprehensive therapy of breast cancer. Method    The domestic and international studies relevant BRCA1 and breast cancer in recent years were reviewed and summarized. Results    BRCA1, a tumor suppressor gene, its mutations caused structural changes and functional abnormalities, which were closely related to breast cancer. And the expression situation and mutation of BRCA1 were associated with the therapeutic effect. Conclusions    Mutation of BRCA1 is closely related to occurrence and development of breast cancer in female. Comprehensive therapy ideas should be found in clinical therapy according to expression or mutation of BRCA1. Further research on BTCA1 is beneficial to explore gold standar