C5-6人工颈椎间盘置换后C3-4椎间孔形态改变的生物力学研究论文.docVIP

　　C5/6人工颈椎间盘置换后C3/4椎间孔形态改变的生物力学研究论文 杨红波，李康华，李雄，李思鸿 【摘要】 目的 了解C5/6髓核摘除、人工颈椎间盘置换对C3/4椎间孔形态改变的影响，探讨出现变化的机制，为颈椎退行性疾病治疗方法的选择提供理论依据。方法 取11具新鲜青壮年尸体颈椎标本，包括C3～T1节段。将位移传感器置入C3/4椎间孔内，在颈椎标本上施加轴向（0～160N）、同侧弯（0～1.5Nm）、对侧弯（0～1.5Nm）、后伸（0～1.5Nm）、前屈（0～1.5Nm）分级载荷.freel负载时的椎间孔高度和宽度都显著性减少，差异有显著性(P 0.05); 在对侧弯、屈曲工况下150N或1.5Nm负载时椎间孔高度和宽度增大，差异有显著性（P 0.05）。（2）在轴向、后伸、同侧弯三种工况相同载荷下，椎间盘髓核摘除组C3/4椎间孔高度和宽度负载前后ROV大于椎间盘完整组和人工椎间盘置换组，差异有显著性（P 0.05）。（3）五种工况下人工椎间盘置换组C3/4椎间孔高度和宽度负载前后ROV与椎间盘完整组比较，差异无显著性（P 0.05）。结论 （1）应用生物力学方法，研究C5/6人工颈椎间盘置换、椎间盘髓核摘除、对C3/4椎间孔孔径改变的影响:C5/6人工颈椎间盘置换后其变化范围与完整组相近; 椎间盘髓核摘除后其变化范围增大。（2）初步证明人工颈椎间盘置换能恢复置换节段椎间盘功能，对C3/4椎间孔孔径变化无不良影响。（3）颈椎间孔高度和宽度：屈曲、对侧弯时增大，轴向、后伸、同侧弯时减小。 【关键词】 颈椎；椎间盘；椎间盘摘除；生物力学；人工椎间盘 The biomechanical research on the changes of C3/4 morphologica after C5/6 cervical artificial disc replacemen 【Abstract】 Objective To reveal the morphological changes of C3/4 intervertebral foramena after the extirpation of vertebral pulp and the replacement of artificial cervical intervertebral disc, and explore the mechanism in order to provide the academic evidence for choice of the therapy of cervical intervertebral disc degeneration.Methods There ples obtained from mens cervical vertebra, including the segments of C3 to T1. The displacement pick-up olateral-bending (0～1.5Nm), oppositeside-bending (0～1.5Nm), back-extending (0～1.5Nm) and anteflexion (0～1.5Nm) easured the morphological changes of C3/4 intervertebral foramena in C5/6 intergrity group, discectomy group and replaced group, the changes in different groups ental data ena in C5/6 intergrity group, discectomy group and replaced group decreased under the loading of 75N or 0.75Nm than those under the loading of 150N or 1.5Nm in the circumstances of axial-bending, homolateral-bending and back-extending. But in the opposite side-bending and inflexion, the height and than those under the loading of 150N or 1.5Nm. The differences had statistical significance (P 0.05). It had statistical meaning that under the same loading of axial-b