链霉蛋白酶联合三联疗法根除幽门螺杆菌临床效果观察.docVIP

链霉蛋白酶联合三联疗法根除幽门螺杆菌临床效果观察 　　[摘要] 目的 观察链霉蛋白酶联合三联疗法根除幽门螺杆菌的临床效果。 方法 随机选取2015年1月～2016年1月我院进行根除HP治疗的患者150例作为研究对象，使用随机数字表将患者分为观察组和对照组，各75例，对照组患者给予常规三联疗法进行治疗，观察组患者在对照组治疗方案基础上给予链霉蛋白酶颗粒。4周后复查，观察两组患者临床疗效、HP根除率以及不良反应发生情况，随诊6个月，观察两组患者HP复发情况。 结果 观察组患者总有效率观察组明显高于对照组（P0.05）。 结论 链霉蛋白酶联合三联疗法对幽门螺旋杆菌具有较好的临床疗效，能提高治疗的有效率和HP根除率，降低其复发率 [关键词] 幽门螺杆菌；链霉蛋白酶；三联疗法；消化性溃疡 [中图分类号] R573 [文献标识码] B [文章编号] 1673-9701（2017）02-0086-03 Observation of clinical efficacy of pronase combined with triple therapy in eradicating helicobacter pylori YIN Qingna Department of Gastroenterology， Huludao Central Hospital of Liaoning Province， Huludao 125000，China [Abstract] Objective To observe the clinical efficacy of pronase combined with triple therapy in the eradication of helicobacter pylori. Methods A total of 150 patients who were given HP treatment in our hospital from January 2015 to January 2016 were randomly selected as the research subjects. The patients were divided into observation group and control group by the random number table， with 75 cases in each group. Patients in the control group were given conventional triple therapy， and patients in the observation group were given pronase granules on the basis of the treatment plan of the control group. The patients were re-examined after 4 weeks， and the clinical efficacy， HP eradication rate and incidence rate of adverse reactions were observed in both groups. The patients were followed up for 6 months， and HP recurrence was observed in both groups. Results The total effective rate in the observation group was significantly higher than that in the control group（P0.05）. Conclusion The combination of pronase and triple therapy has a good clinical effect on helicobacter pylori， which can improve the efficiency of treatment and the eradication rate of HP， and reduce the recurrence rate. [Key words] Helicobacter pylori；Pronase；Triple therapy；Peptic ulcer 幽?T螺杆菌（helicobacter pylori，HP）是目前所知唯一可以在人胃中生存的微生物，属于革兰阴性菌，是胃炎、消化性溃疡等疾病的重要诱因之一，临床研究发现