乳腺癌超声征象与ER、C-erB-2表达的相关性研究.pdfVIP

摘 要 乳腺癌超声征象与 ER、C-erbB-2 表达的 相关性研究 研究生：刘晓萱 导师：于冰 副教授 摘 要 目的：初步探讨乳腺癌超声特征与免疫组织化学因子ER 、C-erbB-2 表达的 相关性，为临床乳腺癌术前辅助治疗及预后判断提供更多的信息和科学依据。方 法: 103例乳腺癌均经病理组织学证实，且所有病例在治疗前均行乳腺超声检查， 术后测定ER 、C-erbB-2 的表达。分析乳腺癌的超声征象与ER 、C-erbB-2 表达 的相关性。结果：1.乳腺癌免疫组织化学因子ER 、C-erbB-2的表达与肿块直径有 相关性。2.有毛刺征的肿块比边缘光整的肿块有更高的ER 、C-erbB-2阳性表达。 3.腋窝淋巴结转移组中C-erbB-2 阳性表达率高，ER 阳性表达率低。4.彩色多普 勒显示血流越丰富，C-erbB-2阳性表达率越高。结论：乳腺癌的超声表现与免疫 组织化学因子之间有一定的相关性。有毛刺征及无淋巴结转移的乳腺癌有更高的 ER 阳性表达率，更适合内分泌治疗；血流丰富、有淋巴结转移者C-erbB-2 阳 性表达率高，预示肿块恶性程度高，预后不良。 关键词： 乳腺肿瘤；彩色多普勒；雌激素受体( ER) ；C-erbB-2 —1— 新疆医科大学医学硕士学位论文 Correlation of color Doppler ultrasound morphologic features with the expression of ER、C-erbB-2 in breast carcinoma Liu xiao-xuan Yu bing Abstract Objective:To preliminarily study the correlation between manifestations of breast carcinoma on the color Doppler ult rasound and the expression of immunohistochemical factors ER， C-erbB-2 ， and to provide more information and scientific evidence for the preoperative adjuvant therapy and for the evaluation of the prognosis1. Methods:103 patients with breast carcinoma on firmed by histopathology were involved in this study.The color Doppler ultrasound was performed in every case before therapy ，and ER， C-erbB-2 were performed after operation. The correlation of the color Doppler ultrasonographic manifestations of breast carcinoma and the expressions of the three factors were analyzed. Results:1.There was a correlation between the si