药物依赖性的神经递质_信号传导机制的研究进展.pdf

trait Pharmaceutical Journal Vol 16 No. 3 2004 - 徐美林, 陈崇宏( 350004) : 　大量研究表明, 神经递质系统如多巴胺递质系统、5-HT 递质系统、谷氨酸递质系统和信号传递 径如AC-cAM P-PKA-CREB、NO- cGMP 、Ca2+ -CaM-CaMK-CREB 等参与了药物( 特别是吗啡类) 依赖性的形成, 进一步探讨它们在依赖中的作用, 可以为最终阐明药物依赖性的 形成机制和研发戒毒药提供新的思路。 : 药物依赖性; 神经递质; 信号通路 : 966: : 1006-3765( 2004) 03-0001-06 R A Progress of the Mechanism of Drug Dependence in Neurot ransmitter and Signal Pathway XU Mei-lin, CHEN Chong-hong( Department of pharmacology, Fujian Medical Uni ersity, Fuzhou, 350004; China) ABSTRACT: everal studies suggested that some neurotransmitters such as dopamine, 5-HT , aminoglutaric 2+ and some signal pathw ays such as AC-cAMP-PKA-CREBNO-cGMPCa -CaM -CaMK-CREB are critically involved in the process of drug dependence, especially morphine like compound; It can offer new idea to clarify finally the mechanism of drug dependence and to research and develop the new drug if w e further explore their role in the drug dependence. ; ; KEY WORDS: Drug dependence Neurotransmit ter ignal pathw ay CREB , , , - , , , , , , 1 , , 1. 1 , , , , , ( M LD ) , ( LC) ( VT A) ( NAc) ( PAG) , , , VT A ( DA ) NAc VTA-NAc , 1, 2 5-HT AC- 2+ VT A DA , NAc DA cAMP-PKA-CREBNO-cGMPCa -CaM -CaM K- 3 , 4 : , , 26, ; , , : 05913574417 , , , , , 58 ,