危重症患者出凝血障碍-培训课件.pptVIP

危重症患者出凝血障碍 Coagulation Disorder Of Critically Ill Patient 止血与凝血过程中的生理平衡机制 生理性止血机制 初级止血过程 血管内皮细胞损伤——暴露胶原、组织因子、vWF因子 血小板粘附：通过GPIb受体连接变构的vWF粘附胶原 血小板激活：局部受损红细胞释放ADP及局部凝血过程中生成的凝血酶均可使血小板活化 血小板聚集：血小板激活后释放内源性ADP及TXA2，促进血小板不可逆聚集 形成白色血栓——血小板血栓 加固止血过程 Introduction Coagulation abnormalities are commonly found in critically ill patients. A myriad of altered coagulation parameters are readily measurable, such as thrombocytopenia, prolonged global coagulation times, reduced levels of coagulation inhibitors, or high levels of fibrin split products. Introduction Prompt and proper identification of the under