小剂量纳洛酮复合新斯的明用于婴幼儿全身麻醉复苏的临床观察.pdfVIP

小剂量纳洛酮复合新斯的明用于婴幼儿麻醉全麻复苏的临床观察 【摘要】 目的：观察小剂量纳洛酮复合新斯的明用于婴幼儿全身麻醉复苏的效 果及其对血流动力学的影响。 方法：选择气管插管全麻婴幼儿54例，随机分为纳洛酮组、阿托品组 和生理盐水组 （对照组），在手术结束、自主呼吸恢复后纳洛酮组给 予纳洛酮0.005mg/kg复合新斯的明0.02mg/kg，阿托品组给予阿托品 0.01mg/Kg复合新斯的明0.02mg/Kg，对照组给予生理盐水5ml,分别观 察和记录给药后0、1、2、3、5、7 患儿SBP和HR，并记录患儿自主睁 眼时间、拔管时间及离开手术室时间，观察三组患儿在气管拔管后的 不良反应及其发生率。 结果：三组病人年龄、体重、性别、婴幼儿比及手术时间无明显差异 （P0.05 ），给药后三组病人的血流动力学指标无明显差异（P）0.05）， 纳洛酮组及阿托品组患儿自主睁眼时间、拔管时间和出室时间明显短 于对照组（P0.05），拔管后出现低氧的患儿明显少于对照（P0.05）。 结论：小剂量的纳洛酮复合新斯的明可以加快婴幼儿的麻醉复苏，对 血流动力学无明显影响。 关键词： 婴幼儿 纳洛酮 新斯的明 全麻复苏 3 Obversation of application of low dose of naloxone and neostigmine during recovery from anesthesia Of infant and children Abstract Objective：To study effect of low dose of naloxone combination of neostigmine on recovery from general anesthesia and hemodynamic Method：Using a double-blind design,15 infants and 45 children scheduled for general anesthesia with intubation were divided randomly into naloxone group and control group.At the end of surgey, naloxone 0.005kg\mg and neostigmine 0.02mg\kg were administrated in naloxone group;5ml normal saline was adminstrated in control group. 0,1,2,3,4,5,6 minutes after administration, SBP and HR were observed and recorded .Time to eye-opening (teo) ,time to tracheal extubation(te) and time to leave operation room （tl ） were also recorded.Incidence of adverse effects were also observed. Results：There were no significant difference in patients as 4 to age,weight,gender,duration of surgery and infant/child ratio.There were also no obvious difference in homedynatics after administration.However,in naloxone group and atropine group, time to eye-opening,time to tracheal extubation and time to leave operation room were shorter than