AIDS2013sha网络稿1.ppt

Acquired Immunodeficiency Syndrome (AIDS) Luc Montagnier Robert C. Gallo 2012.12.125th World Aids Day GET TO ZERO 中国 艾滋病日的宣传主题 “行动起来，向零艾滋迈进”， 副标题 “全民参与，全力投入，全面预防 ” II. Etiology / pathogen HIV, types 1 and 2, a RNA virus . HIV-1, major cause of AIDS worldwide. HIV-2, spreads epidemically in West Africa Peripheral particle, diameter 90-140 nm , retrovirus（反转录病毒）, lentivirus Virion contain 2 copies of a single-stranded RNA genome, products of the viral genes env (glycoprotein [gp] 160, gp120, gp41), gag (p24, p17, p7, p9) and pol (p32, p66, p51, p11) The major targets of HIV infection: CD4+T lymphocyte, macrophage and others CD4+ cells. (B lymphocyte, dendritic cell, stem cell from bone marrow ). 1996, scientists found there were some chemokine receptors (for example, CCR5 and CXCR4) supporting HIV fusion and entry to cell. Chemokines and corecepters of HIV-1 infection CD8+T cells and other CD4+ cells may secrete chemokines, which inhibit HIV infected macrophage and T lymphocyte. CCR5 ligands MIP-1a, MIP-1b and RNATES block M-tropic strains of HIV’s entry, and CXCR4 ligand SDF-1 blocks T tropic strain of HIV’s entry. release virions HIV-1 virions released from T cell III. Epidemiology HIV infection was originally found in United States in 1981, now spreads throughout the world. Fast facts on HIV/AIDSSource: WHO 2012 2.5 million people were newly infected with HIV worldwide in 2011. 1.7 million people died of AIDS-related illnesses worldwide in 2011. 5.25 million HIV-positive people had access to ART in low- and middle-income countries in 2011. 69% of all people living with HIV are in sub-Saharan Africa. 26% of pregnant women were tested for HIV in low- and middle-income countries in 2011. 34.0 million people were living with HIV worldwide in 2011. China, by the end of Oct. 2011 43.4万 HIV 感染者/艾滋病 8.8万 deaths reported Experts estimated there are more than 700,000 persons living with HIV/AIDS in China.