《中药制药分离工程课程设计》芍甘汤提取、精制工艺设计18.docVIP

《中药制药分离工程课程设计》 设计成绩： 批 阅 人： 批阅日期： 设计题目：关于醇沉法制备芍甘颗粒的研究 设计者： 何雨川 班 级： 11级中药制药 学 号： 046211127 指导教师： 郑云峰、李存玉 设计日期： 2013.05.12~2013.05.23 南京中医药大学药学院 目录 一、概述··················································3 1.1 复方组成············································3 1.2 各药介绍············································3 1.2.1 芍药·············································3 1.2.2 甘草·············································4 二、分离技术··············································4 2.1 高速离心技术········································4 2.2 水提醇沉技术········································4 2.3 大孔树脂吸附技术····································5 2.4 超滤技术············································5 三、课程实验···············································5 3.1 实验目的············································5 3.2 仪器试剂············································5 3.3 实验内容············································6 3.4 结果讨论············································8 3.5 注意事项············································8 四、工艺路线··············································9 4.1 处方 4.2 制备工艺　 4.3 工艺流程及工艺说明 五、结束语···············································10 六、鸣谢·················································11 一 概述 本次试验探讨了醇沉法、树脂法、超滤膜法等精制方法对芍药甘草汤的精制效果，并将之应用于芍药甘草颗粒的制备，我们先查询了基础知识，后进行了试验验证，最后进行了工艺探究。 1.1复方组成 【来源】《伤寒论》。 【组成】芍药12克 甘草12克 【用法】上二味，用水600毫升，煮取300毫升，去滓，分温再服。 【功用】调和肝脾，缓急止痛。 【主治】伤寒伤阴，筋脉失濡，腿脚挛急，心烦，微恶寒，肝脾不和，脘腹疼痛。现用于血虚津伤所致的腓肠肌痉挛、肋间神经痛、胃痉挛、胃痛、腹痛、坐骨神经痛、妇科炎性腹痛、痛经；以及十二指肠溃疡、萎缩性胃炎、胃肠神经官能症、急性乳腺炎、颈椎综合征等属阴血亏虚，肝脾失调者。 【方解】本方主治津液受损，阴血不足，筋脉失濡所致诸证。方中芍药酸寒，养血敛阴，柔肝止痛；甘草甘温，健脾益气，缓急止痛。二药相伍，酸甘化阴，调和肝脾，有柔筋止痛之效 【药理】解痉、止痛、抗炎作用。安徽医学院《急腹症资料》1977：74，本方对病变异常兴奋状态有强力的抑制、镇静作用。其中芍药对疼痛中枢和脊髓性反射弓的兴奋有镇静作用，故能治疗中枢性或末梢性的筋系挛急，以及因挛急而引起的疼痛。芍药、甘草中的成分有镇静、镇痛、解热、抗炎、松弛平滑肌的作用，二药合用后，这些作用确能显著增强。[1] 1.2个药介绍 1.2.1芍药 【基源】