《中药制药分离工程课程设计》芍甘汤提取、精制工艺设计6.docxVIP

《中药制药分离工程课程设计》设计成绩：批阅人：批阅日期：芍甘汤提取、精制工艺设计设计者：刘悦班级： 11中药制药学号： 046211102 指导教师：郑云枫设计日期： 2013.05.12~2013.05.28 南京中医药大学药学院一、设计任务书1.设计题目芍甘汤提取、精制工艺设计2.设计条件芍甘复方片剂提取物的工艺设计3.设计内容与要求（1）确定提取工艺及参数；（2）确定精制分离工艺及参数；（3）提取物得率、成分含量以及相对密度；（5）编写设计说明书；4.设计成果（1）设计说明书一份包括概述（简要说明所设计的复方中药效物质成分类型、性质及药理作用等）；常用精制分离技术简述（主要为高速离心、醇沉、大孔树脂吸附以及超滤）课程实验（不同精制方法的效果及比较）；工艺线路的设计（从最终制剂的剂型、工艺合理性以及生产成本等方面考虑）。（2）芍甘汤提取精制工艺流程图；5.设计时间设计时间为2周，从2013年5月12日至2013年5月23日。二、目录封面···········································································1一、设计任务书······························································2二、目录·······································································3三、概述·······································································4四、常用精制分离技术简述··············································6高速离心·······························································6醇沉·····································································6大孔树脂吸附·························································7超滤·····································································8五、课程实验报告···························································9六、工艺线路设计·························································16七、结束语··································································20八、参考文献·······························································20三、概述1. 芍甘汤简介名称：芍药甘草汤此方来源于《伤寒论》，其组成为芍药12克、甘草12克，功用是调和肝脾，缓急止痛，主治津液受损，阴血不足，筋脉失濡所致诸证，如伤寒伤阴、筋脉失濡、腿脚挛急等。方中芍药酸寒，养血敛阴，柔肝止痛；甘草甘温，健脾益气，缓急止痛。二药相伍，酸甘化阴，调和肝脾，有柔筋止痛之效。用法：12g芍药和12g甘草加水煎煮两次，合并煎液，分两次服用，早晚各一次。2. 芍甘汤药效物质2.1甘草的成分研究甘草主要有效成分是三萜类化合物和黄酮类化合物。三萜类化合物是一类基本母核由30个碳原子组成的萜类化合物。甘草中的主要三萜类成分是甘草酸，其钾、钙盐为甘草甜素，是甘草中的甜味成分。此外还含有甘草皂苷等三萜皂苷以及甘草次酸、甘草次酸甲酯、甘草内酯等三萜皂苷元。甘草酸是甘草中的主要三萜类成分，也是甘草的主要药效成分和指标性成分。甘草酸为无色或白色柱状结晶，味极甜，约为砂糖的250倍，熔点为220℃（分解），旋光度+46.2°（c=1.5，乙醇），易溶于热水、乙醇，几乎不溶于乙醚。黄酮类化合物是一类具有C6-C3-C6基本母核的天然产物，广泛存在于自然界中。甘草中的黄酮类化合物分属黄酮（醇）、异黄酮、查尔酮、二氢黄酮（醇）、异黄烷、异黄烯等，主要有甘草苷、甘草素、异甘草苷、异甘草素、新异甘草苷、芒柄黄苷等。黄酮类化合物多呈黄色结晶性固体，少数为无定形粉末，多具有旋光性。游离黄酮类化合物一般难溶或不溶于水，易溶于有机溶剂及稀碱水溶液中；黄酮苷类水溶性增加