皮肤干细胞.pdf

bs_bs_banner Pathology International 2015; 65: 415–419 doi:10.1111/pin.12320 Original Article Aging rather than sun exposure is a major determining factor for the density of miR-125b-positive epidermal stem cells in human skin Shinya Toyokuni,1 Li Jiang,1 Shenqi Wang,1 Ayaka Hirao,2 Tamae Wada,2 Chieko Soh,3 Kazumi Toyama3 and Akira Kawada2 1Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, 2 Department of Dermatology, Kinki University School of Medicine, Osaka and 3 Kobe Technical Center, Procter Gamble, Kobe, Japan Sunlight exposure and aging are two major factors in the cell types in tissue. These properties are the basis of tissue deterioration of skin function. In the present study, we used homeostasis, wound-healing and most likely tumor growth.8 eighty formalin-fixed human skin samples from sun- Increasing evidence has suggested that microRNAs (miRs) exposed and unexposed areas from old and young individu- are important modulators of development and, thus, of stem als to evaluate the presence of miR-125b-positive epidermal cells via their ability to simultaneously silence hundreds of stem cells (ESCs) by in situ hybridization. miR-125b- positive ESCs were detected in the basal layer of the epi- target genes.9 Recently, miR-125b was shown to work as a dermis. The density of miR-125b-positive ESCs was repressor of stem cell differentiation in the epidermis and to significantly associated with age rather than sun expos