降压：联合用药优于单药加量.pdfVIP

Papers should not preclude the use of statins in the prevention 3 Gould AL, Rossouw JE, Santanello NC, Heyse JF, Furberg CD. of cardiovascular disease. The evidence is clear: statins Cholesterol reduction yields clinical benefit. Impact on statin trials. Circu- lation 1998;97:946-52. substantially reduce IHD events (by 61%), and prevent 4 Law MR, Wald NJ, Thompson SG. By how much and how quickly does stroke by 17% overall, through the prevention of non- reduction in serum cholesterol concentration lower risk of ischaemic heart disease? BMJ 1994;308:367-72. fatal strokes with little effect on the risk of fatal stroke. 5 Crouse JR, Byington RP, Furberg CD. HMG-CoA reductase inhibitor Any possible excess of haemorrhagic stroke is greatly therapy and stroke risk reduction: an analysis of clinical trials data. Atherosclerosis 1998;138:11-24. outweighed by the protective effect against IHD events 6 Blauw GJ, Lagaay AM, Smelt AHM, Westendorp RGJ. A meta-analysis of and thromboembolic stroke. randomised, placebo controlled, double-blind trials with HMG-CoA reductase inhibitors. Stroke 1997;28:946-50. We thank the following authors for unpublished data from 7 Hebert PR, Gaziano JM, Chan KS, Hennekens