辅助性T淋巴细胞的训男究进展.pptVIP

Trends in Helper T cells;Naive T;Th1/ Th2 balance Th17 Th9 T22 Tfh;Th1/Th2 Balance;Th1 Cells;Th2 Cells;The major?lymphokines?secreted by Th2 cells are interleukin 4?(IL-4). This stimulates?class-switching?in B cells and promotes their synthesis of?IgE?antibodies. acts as a positive-feedback device promoting more pre-Th cells to enter the Th2 pathway. blocks the IFN-γ receptors from entering the?immunological synapse?on pre-Th cells thus inhibiting them from entering the Th1 path (shown in red). Interleukin 13?(IL-13). This also promotes the synthesis of?IgE?antibodies as well as recruiting and activating?basophils. Interleukin 5?(IL-5). Attracts and activates?eosinophils. ;Th1/Th2细胞分化调节;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;黏附分子的作用：朗罕细胞细胞向Th1细胞提呈抗原需要黏附分子，向Th2细胞提呈抗原无需黏附分子参与。 激素作用：糖皮质激素增强Th2细胞活性，脱氢表雄甾酮可增强Th1细胞活性;Th1/Th2细胞亚群的效应功能;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;Th1与Th2的平衡;transcription factors ;;Th1/Th2与临床;Th1/Th2与治疗;Th17;Th17的发现;All:4286 ;Nature 453, 1051-1057 (19 June 2008) | Review：Induction and effector functions of TH17 cells Estelle Bettelli1, Thomas Korn1,2, Mohamed Oukka1 Vijay K. Kuchroo1 Here we review emerging data suggesting that TH17 cells have an important role in host defence against specific pathogens and are potent inducers of autoimmunity and tissue inflammation. In addition, the differentiation factors responsible for their generation have revealed an interesting reciprocal relationship with regulatory T (Treg) cells, which prevent tissue inflammation and mediate self-tolerance.;TH1;Th17的命名;Th17细胞的分化;Th17细胞的分化;Th17细胞的分化;Th17细胞的分化;Th17细胞的分化;　Th17细胞的生物学功能;　IL-17细胞的生物学功能;Th17细胞的生物学功能;Th17细胞与疾病;Th17 and cancer;;Th0;Th9;　Th9细胞的诱导产生和分化;Transcriptional network in Th9 cells