人脑内谷氨酸水平活体磁共振波谱定量分析和其在精神疾病中.PDFVIP

第33 卷 第4 期 中国医学物理学杂志 Vol. 33 No.4 2016 年 4 月 Chinese － －393 Journal of Medical Physics April 2016 DOI:10.3969/j.issn.1005-202X.2016.04.015 脑科学与神经物理 人脑内谷氨酸水平活体磁共振波谱定量分析及其在精神疾病中的 应用 刘希垄，李龙 广州医科大学附属武警广东省总队医院放射科，广东广州510507 【摘 要】大量研究表明精神疾病患者脑内谷氨酸水平异常，磁共振波谱技术是一种在活体上无创定量检测组织内代谢物 浓度的方法。谷氨酸在中枢神经系统内是最主要的兴奋性神经递质，但其浓度较低并与其它代谢产物相重叠，所以谷氨 酸检测通常需要波谱编辑法来完成。本文对检测谷氨酸的磁共振波谱编辑方法及其在精神疾病中的应用进行综述。 【关键词】谷氨酸；神经递质；磁共振波谱；精神疾病；综述 【中图分类号】R445.2 【文献标识码】A 【文章编号】1005-202X（2016）04-0393-06 Quantitative detection of glutamate in human brain by magnetic resonance spectroscopy in vivo and its application in mental disorders LIU Xi-long, LI Long Department of Radiology, Guangdong Provincial Corps Hospital of Chinese Peoples Armed Police Forces, Guangzhou Medical Univer- sity, Guangzhou 510507, China Abstract:Considerable evidences in the study of mental disorders have shown the level of glutamate (Glu) in patients brain is abnormal. Magnetic resonance spectroscopy (MRS) allows the directly non- invasive quantitative detection in vivo for endogenous metabolites in human brain. Although Glu is the most abundant excitatory neurotransmitter in the central nervous system, its detection is usually achieved by spectral editing methods because of the low concentration and overlapping with other metabolites. The MRS spectral- editing methods proposed for detecting Glu and its application in mental disorders were summarized in the paper. Keywords:glutamate; neurotransmitter; magnetic resonance spectroscopy; mental disorders; review 前言 1 Glu 的生理功能 神经递质是指在神经末梢合成并释放的特殊化 Glu 是人脑内最主要的兴奋性神经递