间接药动_药效模型参数计算程序.pdf

学 报 Jo rnal of China Pharmace tical University 2007, 38 ( 1) : 55- 59 55 陈渊成, 曹彦光, 郝 琨, 柳晓泉 , 王广基 ( , 210009) :根据Dayneka 等人提出的间接药动学药效模型,设计一种计算机程序, 用于估算间接药动学药效模型 的参数:联合应用 传算法和规划求解同时拟合给药后血药浓度时间和效应时间的数据, 估算相应的药动学和药 效学参数: 以口服一房室模型为例, 对华法林的间接药动学和药效学结合模型的曲线进行拟合, 算得 PK 参数 tmax ( 340 152) h, c (5639 685) g/ mL, t (2014 566) h; PD 参数K (0100 9 0019 3) h- 1, K (0093 8 0017 4) h- 1, max 1/ 2 in o t IC ( 3732 1336) mg/ L: 该程序可用于间接药动学药效模型参数的求算, 并同时描述药物的药动学和药效学行为 50 特征 间接药动学药效学模型; 华法林; 传算法; 规划求解 R969. 1 A 1000- 5048(2007) 01- 0055- 05 Program design of indirect pharmacokinetic and pharmacodynamic model CHEN Y ancheng, CAO Yang ang, HAOk n, LIU Xiaoq an, WANG G angji Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanj ing 21 9, China Abstract Aim: A programme was designed to obtain the parameters of indirect pharmacokineticpharmacodynamic model proposed by Dayneka. Methods: Using both genetic algorithm and planning sol tion, the parameters of the model can be estimated thro gh sim ltaneo s fitting of concentrationtime data and responsetime data. Results: Tak ing one compartment model following oral administration as example, the pharmacokinetic parameters val e from c rve fitting of the model of warfarin were: tmax ( 340 152) h, cmax ( 5639 685) g/ mL, t1/ 2 ( 2014 566) h; the - 1 - 1 pharmacodynamic parameters val e were K ( 0100 9 0019 3) h ,K ( 0093 8 0017 4) h , IC ( 3732 in