简化球谐近似与Laplace正则化的荧光分子断层成像方法_.pdfVIP

2015 年2 月 西安电子科技大学学报（自然科学版） Feb.2015 第42 卷 第1 期 JOURNAL OF XIDIAN UNIVERSITY Vol.42 No. 1 doi：10.3969/j.issn.1001-2400.2015.01.013 简化球谐近似与Laplace 正则化的荧光分子断层成像方法 李 维, 易黄建，张岐坦，梁继民 (西安电子科技大学 生命科学技术学院，陕西 西安710071) 摘要：荧光分子断层成像作为一种先进的光学分子影像，可以有效重建小动物体内荧光团的浓度和三维 空间分布信息，实现肿瘤的早期检测。为了提高重建的图像性能，针对扩散模型只适合高散射低吸介质 的局限性，采用基于辐射传输方程的简化球谐近似模型进行前向模拟，同时为克服重建过程的病态性， 应用一种融合结构信息的Laplace 正则化方法进行图像重建。数值仿真实验结果表明该方法能够获得较 高质量的重建图像，尤其对于小荧光团和多荧光团成像。 关键词：荧光成像；断层成像；简化球谐波近似；正则化 中图分类号：TP391.41 文献标识码：A 文章编号：1001-2400(2015)01-0089-05 Fluorescence molecular tomography method using simplified spherical harmonics approximation and Laplace regularization LI Wei, YI Huangjian, ZHANG Qi tan, LIANG Jimin (School of Life Sciences and Technology, Xidian Univ., Xi’an 710071, China) Abstract: As an emerging optical molecular imaging technology, fluorescence molecular tomography can efficiently reconstruct concentrations and three dimensional distributions of the buried fluorophore in small animals and diagnose early cancer. For the purpose of improving the performance of the reconstructed image, simplified spherical harmonics approximation (SP ) based on radiative transport equation (RTE）is proposed to N perform the forward simulation. To overcome the influence of the ill-posedness and receive a more accurate reconstructed image, Laplace regularization method is introduced to reconstruct the inverse problem. The numerical experiments reveal that th