六种辛凉解表类中药挥发油化学成分的比较研究.pdfVIP

天然产物研究与开发 Nat Prod Res Dev，2007，19：218-222 文章编号：1001-6880{2007)Suppl-0218-05 六种辛凉解表类中药挥发油化学成分的比较研究 刘新湘 ，赵晨曦 ，梁逸曾¨ 中南大学中药现代化研究中心，长沙410083； 长沙学院生物工程与环境科学系，长沙410003 摘 要：主要采用气相色谱-质谱法对六种辛凉解表类中药(薄荷、柴胡、葛根、菊花、桑叶、牛蒡子)挥发油化学 成分进行定性定量分析，采用色谱保留指数法辅助定性，对重叠色谱峰运用直观推导式演进特征投影(HELP) 法解析。在理论上阐述了六种辛凉解表类中药的指纹图谱和挥发油成分方面的共性和差异。得出此类中药挥 发油的指纹图谱差异较大，化学成分以萜烯、醛、醇、酮类物质为主，且不能以某几种化合物作为此类中药的有 效成分等结论。结果为此类药物挥发油化学成分和特征成分研究提供依据，但药理药效研究还要进一步从中 药的协同作用开展。 关键词：气相色谱-质谱法；辛凉解表中药；挥发油；色谱保留指数；直观推导式演进特征投影法 中图分类号：R284．2 文献标识码：A Comparative Study on Chemical Components in Essential oils from Six Pungent Traditional Chinese Medicines LIU Xin．xiang ，ZHAO Chen-xi ．_，HANG Yi．zeng ’ Research Center of MDdem屯肌泌，I of Tradiffonal Chinese Medicine．Central South University，Changsha 410083，China； Department ofBiological En#rteering arm Environmental Science，Changsha University，Changsha 410003，Chins Abstract：The constituents ofvolatile oils from six pungent traditional Chinese medicines(TCMs)(herba Menthae，Ra- dix bupleud，Radix puerariae，Flos chrysantheml，Folirm mori and Fructus arctii)for relieving the exterior syndrome were mainly identified by GC／MS with the assistant of gas chromatography retention index and with the help of heuristic evol- ving latent projeetions(HELP)resolution．Differences and commonness of the fingerprints and chemical components in essential oils from the six pungent traditional Chinese medicines were studied in theory．Results obtained in this paper showed that GC fingerprints and components of the six TCMs were different obviously．Chemical components in the es- sential oils were mainly terpenes，aldehydes，alcohols and ketones．So it is difficult to con