益生菌对雌激素代谢及相关疾病的影响.pdfVIP

248 2016, Vol.37, No.11 食品科学 ※专题论述 丁 佳，王慧艳，何秋雯，郭丽如，张和平* （内蒙古农业大学乳品生物技术与工程教育部重点实验室，内蒙古 呼和浩特 010018 ） 摘 要：近年来，因雌激素代谢紊乱引起的女性健康问题受到国内外学者的广泛关注。有研究发现肠道微生物及其 多样性对女性雌激素代谢及其代谢产物有重要影响，而经过益生菌干预后可改善肠道菌群结构，促进有益菌生长， 进而改善机体雌激素代谢。此外，益生菌能够调节有机体内血液循环及内分泌循环系统，从而改善因雌激素代谢紊 乱而诱发的一系列疾病。本文对国内外益生菌与雌激素相关疾病的研究现状进行综述，并列举了益生菌对改善雌激 素代谢紊乱在临床治疗中的应用，为雌激素代谢紊乱及相关疾病的防治提供一定参考。 益生菌；肠道微生物；雌激素；雌激素代谢紊乱 Effects of Probiotics on Estrogen Metabolism and Related Disorders * DING Jia, WANG Huiyan, HE Qiuwen, GUO Liru, ZHANG Heping (Key Laboratory of Dairy Biotechnology and Bioengineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China) Abstract: ’ In recent years, women s health problems caused by estrogen metabolic disorder have drawn great public attention. Some studies show that the gut microbiota has a significant impact on the host estrogen metabolism and its metabolites. The application of probiotics can improve the intestinal microbiota by promoting the growth of beneficial bacteria, thereby improving the estrogen metabolism in the body. Besides, probiotics can regulate the host blood circulation, thus improving a wide spectrum of estrogen metabolism-related disorders. This paper reviews the current knowledge of probiotics in relation to estrogen-related diseases, as well as the clinical application of probiotics in preventing and treating estrogen metabolic disorders. Key words: probiotics; gut microbiota; estrogen; estrogen metabolic disorders DOI:10.7506/spkx1002-6630-201611044 中图分类号：TS201.3