宫糜康栓剂的制备及临床疗效观察.PDFVIP

宫糜康栓剂的制备及临床疗效观察 宋卫青( 山西省活血化瘀研究所，太原 030001) 摘要：目的 研制中药制剂宫糜康栓的制备及质量控制方法，观察其临床疗效。方法 将方中各药味粉碎成细粉制成宫 糜康栓剂，进行临床疗效观察。结果 治疗组 100 例，治愈：64 例，显效 21 例，有效 11 例，无效 4 例，总有效率为 96% ； 宫糜康散剂对照组 100 例，治愈：66 例，显效 20 例，有效 12 例，无效 2 例，总有效率为 98%。结论 宫糜康栓剂制备 工艺简单，质量可控，疗效确切。 关键词：宫糜康栓；制备；质量控制；临床疗效 中图分类号：R944.23 ；R969.4 文献标志码：B 文章编号：1007-7693(2010)13-1199-02 Study on Preparation and Clinical Effect of Gongmikang Suppository SONG Weiqing(Shanxi Province Institue of Activating Blood Flow and Blood Stisis, Taiyuan 030001, China) ABSTRACT: OBJECTIVE To prepare Gongmikang suppository and observe its clinical effects. METHODS Various ingredients of the prescription were crushed into fine powder and then Gongmikang suppository was made and its clinical effects were observed. RESULTS The number of healing cases, obviously effective cases, efficient cases of curative group was 64, 21, 11 and 4, respectively. Overall efficiency was 96%. Compared with control group, the number was 66, 20, 12 and 2, respectively and overall efficiency was 98%. CONCLUSION The process and quality control of the suppository are simple and it is effective. KEY WORDS: Gongmikang suppository; preparation; quality control; clinical effect 宫颈糜烂、宫颈炎是妇科常见病。本制剂处 再取小檗碱对照品，加甲醇制成每 1 mL 含 0.5 mg 方是于载畿教授的经验方，具有泻热解毒，祛腐 的对照品溶液。照薄层色谱法[1]实验，吸取上述供 生肌的功效，经过多年临床观察，本方治疗宫颈 试品溶液、对照药材溶液各 2 μL ，对照品溶液 糜烂、宫颈炎有效。 1 μL ，分别点于同一硅胶 G 薄层板上，以正丁醇- 1 处方与制备 冰醋酸-水(7 ∶1 ∶2)为展开剂，展开，取出，凉干， 1.1 处方 置紫外光灯(365 nm)下检视。供试品色谱中，在与 黄柏 676 g，墓头回 244 g ，雄黄 130 g。 对照药材色谱相应的位置上，显相同颜色的荧光 1.2 制备 斑点，在与对照品色谱相应的位置上，显相同的 将雄黄水飞成极细粉，另两味粉碎成细粉， 黄色荧光斑点。 过筛，混匀。另取聚氧乙烯硬脂酸酯 554 g，加热