肠道微生物与人体健康综述.pdfVIP

第 4 卷 第4期 集 成 技 术 Vol. 4 No. 4 2015年7月 JOURNAL OF INTEGRATION TECHNOLOGY Jul. 2015 肠道微生物与人体健康综述 颜晓庆 陈宏运  吴彬彬  刘春花  梁 岩 (中国科学院深圳先进技术研究院食品安全及环境技术研究室 深圳 518055) 摘  要  人体肠道中含有大量的微生物。研究表明，肠道微生物的群落结构在人体的许多生理功能上发挥重要作 用，如机体物质代谢、能量吸收、胃肠道功能的完善及免疫功能的调节等。人体的许多慢性疾病，比如肥胖症、 与肥胖相关的炎症反应、炎症性肠病、抑郁症等都与胃肠道微生物的群落结构失衡有关。肠道微生物与人体相互 作用关系的研究对许多慢性病的预防和治疗，以及保持人体健康具有一定的指导意义。 关键词  肠道微生物；肥胖；肠道移植；植物发酵液 中图分类号  Q 939.93 文献标志码  A The Review of Gut Microbiota and Human Health YAN Xiaoqing CHEN Hongyun WU Binbin LIU Chunhua LIANG Yan ( Laboratory for Food Safety and Environmental Technology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China ) Abstract The human gut is densely populated by the gut microbiota. There are accumulating evidences indicating that the gut microbiota plays a significant role in the function of the body, which including the metabolism and energy absorption, the development in the function of gastrointestinal, the modulation of immune system and so on. Many chronic diseases, such as obesity, obesity-associated inflammation, inflammatory bowel disease and depression, are related to gut microbiota dysbiosis. The research of the interaction between intestinal bacteria and human body is instructive to the prevention or treatment of many chronic diseases and maintaining health. Keywords gut micobiota; obesity; intestinal transplantation; plant fermentation extract 口腔和胃肠道中。其中，肠道是这个复杂微生物 1 引 言 群区系的“大本营”。人类内源性的肠道微生物 是提供营养、调控上皮细胞生长以及指示内在免