2型糖尿病合并高尿酸血症基质金属蛋白酶-9的变化与左心室重构的相关性.docVIP

合并高尿酸血症的2型糖尿病患者基质金属蛋白酶-9的变化与左心室重构的相关性及其干预治疗的研究 山东省莱芜市人民医院 干部科 吴茂红 Type 2 diabetes Combined hyperuricemia change in matrix metalloproteinase-9 and left ventricular remodeling and its therapeutic intervention Laiwu People’s Hospital ,laiwu Shandong wu mao hong Abstract : Objective: To research combination of hyperuricemia in patients with type 2 diabetes blood uric acid (UA), matrix metalloproteinase -9 levels and left ventricular remodeling, Observed clinical effect after the intervention concept . Methods: Choose 100 cases type 2 diabetes patients with hyperuricemia to be hyperuricemia Group,50 cases of normal uric acid in patients with type 2 diabetes was DM group. Two groups of patients were detected in blood glucose, blood lipids, glycosylated hemoglobin, serum uric acid, matrix metalloproteinase-9 Levels. Two groups of patients wee echocardiography detected .Compare these indicators .The hyperuricemia group was randomly divided into treatment group and control group. Control group was treated with hypoglycemic .Treatment group was given allopurinol, benzbromarone, alkaline urine therapy on the basis of the hypoglycemic treatment. They were treated for 6 months。Results: TG, uric acid, serum MMP-9 Quality Concentrations of hyperuricemia group were significantly higher than those of the diabetic group, left ventricular posterior wall thickness (LVPWT), end-diastolic interventricular septum thickness (IVST), left ventricular mass index (LVMI) in hyperuricemia group was significantly higher than those in the simple urine disease group, End-diastolic left ventricular internal diameter (LVEDD), LVEF in the two groups was not Different . Left ventricular mass index (LVMI) and blood uric acid, TG, serum MMP-9 quality concentration were positively correlated ，correlation coefficients were r = 0.435, r = 0.348, r = 0.356, P = 0.001, After treatment, TG, uric acid, MMP-9, left ventricular posterior wall thickness (LVPWT), end-diastolic interventricular septu