降钙素基因相关肽及青壮年胆汁反流关系探析.docVIP

降钙素基因相关肽及青壮年胆汁反流关系探析[摘要] 目的 探讨降钙素基因相关肽与青壮年胆汁反流的关系。方法 对45例青壮年胆汁反流患者幽门区黏膜降钙素基因相关肽含量进行测定，与45例对照组进行比较，并测定胆汁反流组胃液胆汁酸浓度。结果 青壮年胆汁反流患者的幽门区黏膜降钙素基因相关肽含量较对照组降低（P＜0.05），与胃液胆汁酸浓度无明显相关。结论 青壮年胆汁反流胃炎患者胃黏膜中降钙素基因相关肽含量降低，可能是胃黏膜适应性保护机制之一 [关键词] 胆汁反流；降钙素基因相关肽；胃液胆汁酸；青壮年 [中图分类号] R575.7 [文献标识码] B [文章编号] 1673-9701（2011）33-155-02 The Relationship of Calcitonin Gene-related Peptide and Bile Reflux in the Young and Middle-aged Patients ZHANG Lijin LIN Zhihui ZHENG Xiaoling FANG Chaoying Fujian Provincial Hospital，Fuzhou 350001，China [Abstract] Objective To study the relationship of calcitonin gene-related peptide and bile reflux in the the young and middle-aged patients. Methods Pyloric mucosal calcitonin gene-related peptide concentration of 45 young and middle-aged patients with bile reflux and 45 control group were detected. Endogastric bile acid of the young and middle-aged patients with bile reflux were detected simultaneously. Results The level of pyloric mucosal calcitonin gene-related peptide concentration was decreased evidently in young and middle-aged patients with bile reflux. Compared with control group，the difference has statistics significance（P＜0.05）. There is no distinct correlatationship among calcitonin gene-related peptide and endogastric bile acid. Conclusion The decrease of gastric mucosal calcitonin gene-related peptide may be involved in the gastric mucosa adaptive protection of bile reflux in the young and middle-aged patients. [Key words] Bile reflux；Calcitonin gene-related peptide；Endogastric bile acid；Young and middle-aged people 随着胃镜检查的普及，临床上青壮年胆汁反流的检出率比较高，但原因不明。本研究旨在通过对45例青壮年原发性胆汁反流患者幽门区黏膜降钙素基因相关肽（CGRP）含量及胃液胆汁酸浓度的测定，探讨降钙素基因相关肽在青壮年胆汁反流发病中的作用 1 资料与方法 1.1 一般资料 选择非术后、幽门完整且不伴有消化性溃疡、胃十二指肠肿瘤及胆道疾病的青壮年，内镜检查明确为胆汁反流Ⅲ度（黄色液体从幽门口频繁涌出或（和）持续性喷射出或胃内布满黄绿色潴留液）的患者共45例，全部来自我院消化内镜中心2009年8月～2011年6月的门诊患者，其中男19例，女26例，年龄19～45岁，平均33.9岁（有5例患者胃镜检查前曾行24小时胃内胆汁监测确定存在碱反流）。同步选择45例内镜检查无明显异常的青壮年健康体检者为对照者，男21例，女24例，年龄20～45岁，平均31.2岁。排除消化系统器质性病变，如消化道肿瘤，肝、胆、胰、肠道病变等，排除肝胆胃