Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage：（独特的基因组和蛋白质组和守恒的特性的发热,早期分裂的冠状病毒组2血统）.pdfVIP

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Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage：（独特的基因组和蛋白质组和守恒的特性的发热,早期分裂的冠状病毒组2血统）.pdf

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Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage：（独特的基因组和蛋白质组和守恒的特性的发热,早期分裂的冠状病毒组2血统）

doi:10.1016/S0022-2836(03)00865-9 J. Mol. Biol. (2003) 331, 991–1004 Unique and Conserved Features of Genome and Proteome of SARS-coronavirus, an Early Split-off From the Coronavirus Group 2 Lineage Eric J. Snijder1*, Peter J. Bredenbeek1, Jessika C. Dobbe1 2 2 3 3 Volker Thiel , John Ziebuhr , Leo L. M. Poon , Yi Guan 4 1 1* Mikhail Rozanov , Willy J. M. Spaan and Alexander E. Gorbalenya 1Molecular Virology Laboratory The genome organization and expression strategy of the newly identiﬁed Department of Medical severe acute respiratory syndrome coronavirus (SARS-CoV) were pre- Microbiology, Leiden dicted using recently published genome sequences. Fourteen putative University Medical Center open reading frames were identiﬁed, 12 of which were predicted to be Room L4-34, Albinusdreef 2 expressed from a nested set of eight subgenomic mRNAs. The synthesis P.O. Box 9600, 2300 RC Leiden of these mRNAs in SARS-CoV-infected cells was conﬁrmed experimen- The Netherlands tally. The 4382- and 7073 amino acid residue SARS-CoV replicase poly- 2 proteins are predicted to be cleaved into 16 subunits by two viral Institute of Virology and proteinases (bringing the total number of SARS-CoV proteins to 28). A Immunology, University of ¨ ¨ phylogenetic analysis of the replicase gene, using a distantly related toro- Wurzburg, Wurzburg virus as an outgroup, demonstrated that, despite a number