热休克蛋白90α在HBV相关性肝细胞癌中的表达及临床意义.pdfVIP

结论： 1）HSP90α 与HBV 相关性肝细胞癌的侵袭转移相关。 2）HSP90α 可望成为HBV 相关性肝细胞癌侵袭转移、预后评估及区分HBV 相关性 肝病与健康者的标志物之一。 关键词： 热休克蛋白90 α；HBV 相关性肝细胞癌；侵袭及转移 3 万方数据 Expression of heat shock protein 90 αin HBV-related hepatocellular carcinoma and its Clinical Significance Major ：Pediatrics M ．D ．Candidate ：Li Hui Supervisor Prof ．：Li Wei Hua Abstract Background: HSP90 is a class of widely present in eukaryotic cells highly conserved molecular chaperones, a growing number of studies have shown that it plays an important role in tumor cell proliferation and differentiation, survival, and mobile and angiogenesis, has become a new cancer treatment target.According to whether they contain rich snippets of glutamic acid amine, Human HSP90 divided into two categories, HSP90ɑ and HSP90β, recent studies have shown that HSP90ɑ, not only in the cell and the expression on the cell surface, even secretion to work outside the cell, and is closely related to high tumor invasion and metastasis. Primary hepatocellular carcinoma is one of malignant tumors with high morbidity and high mortality, has become a worldwide problem of serious harm to human health, molecular biology and epidemiological studies have confirmed that Hepatitis B virus (HBV) infection is a major cause of chronic hepatocellular carcinoma (HCC) . Because of HCC mortality is extremely tal