冠心病病人血清胆红素及血脂变化与冠脉病变的关系.pdfVIP

578 Chin J Hemorh．2007；1 7(4) 冠心病病人血清胆红素及血脂变化与冠脉病变的关系 韩 冷，王志强，蔡墨华 (江苏省常熟市第一医院心内科，江苏常熟 215500) 摘要：目的 探讨血清中胆红素及血脂水平与冠心病之间的关系。方法 42例病人，经冠脉造影证实为冠心病者23 例，冠脉造影正常的l9例。另外，诊断明确的急性心肌梗死病人l5例。取血测定血清胆红素及血脂，比较冠心病病人 和对照组之间有无变化。结果 冠心病组病人LDL．C较对照组咀显增高而DB1L明显降低，l两组相比具有显著差异性f尸O．05)。 虽然冠心病病人TC、TG较对照组增高，而HDL及TBIL较对照组降低，但两组相没有显著差异性。急性冠脉综合症病 人与稳定性心绞痛病人相比，虽然LDL．C较高，TBIL较低，但两组相比没有差异性，而DB1L较低，两组相比具有显 著差异性(|P0．05)。结论 血清中胆红素和LDL．C参_卜丁冠心病的发生，血清中胆红素可能参与了急性冠脉综合症的发生。 关键词：冠心病；胆红素；血脂 中图法分类号：R541．4 文献标识码：A 文章编号：1009—881X(2007)04—0578—02 Study on the Relationship between Serum Bilirubin and Lipid and Coronary Heart Disease HANLeng,WANG Zhi··qiang,CAIMo··hua (Department of Cardiovascular Medicine，First Hospital of Changshu，Changshu 2 1 5500) Abstract：Objective To investigate the relationship between serum bilirubin as well as lipid and coronary heart disease．Method 42 paients with coronary angiography and 1 5 patients with acute myocardial infarction were enrolled in this study．Serum bilirubin and lipid were assayed and compared their changes in different groups． Results Serum LDL—C levels increased significantly in patients with coronary heart disease and serum bilirubin decreased significantly．Changes of other lipid levels and TBIL did not reach significantly，Serum levels ofDBIL in patients with acute coronary syndrome increased significantly compared with stable angina pectoris．And other parameters showed no significance．Conclusion Changes of LDL—C and bilirubin were related to patients with coronary heart disease．Changes of bilirubin were only related to patients with acute coronary syndrome． Key words：coronary heart disease；bjlirubin；1Ipid 胆红素是在肝细胞内经过复杂的化学反应代谢 1 资料与方法 转变而成，既往临床 1-作中注重其含量升高的意 义，而对其生理意义的研究较少。近年来的研究表 1