吉西他滨联合5-Fu和CF治疗晚期乳腺癌.pdfVIP

Chin J Hemorh．2007；1 7(4) 吉西他滨联合 5-Fu和CF治疗晚期乳腺癌 余建和 (江苏省兴化市人民医院，江苏必化 225700) 摘要：目的 评价吉西他滨联合氟尿嘧啶(5．Fu)／甲酰四氢叶酸CCF)组成的GLF方案作为二线方案治疗晚期乳腺癌的疗 效和毒性。方法 38例既往曾接受蒽环类和／或紫杉类方案化疗的晚期乳腺癌患者，采用GLF双刷方案，即吉西他滨1， 200mg／m2静脉滴注，CF200mg／m2，经静脉滴注5．Fu 325mg／m2，先静脉推注，然后2．8mg／m2持续48h滴注；每2周重 复1次，每2次为1周期。结果38例中CR 2例、PR 14例、NC 1 3例、PD 9例，总有效率为42．1％。ⅡI～Ⅳ度白细 胞下降为】8．42％，II1度血小板下降为7．91％，I『『度粒膜炎】0．5％，其他不良反应轻微。结论 吉西他滨联合5．Fu及CF组 成GLF双周方案作为二线方案对蒽环类和／或紫杉类方案耐药的晚j}u乳腺癌疗效令人满意，不良反应少，值得进一步研究。 关键词：乳腺癌；联合用药；吉西他滨 中图法分类号：R737．9 文献标识码：A 文章编号：1009—88ixC2oo7)o4．-0594．-02 Gemeitabine plus 5-Fluorouraci l／Leucovorin in the Treatment of Advanced Breast Cancer YUd／,an．he (Xinghua People’S Hospital，Xinghua 225700) Abstract：Objective To evaluate thle~fficacy and toxicity ofgemcitabine plus 5一fluorouracil／leucovorin in 1he treatment of advanced breast cahcer resistant to anthracyclines and／or taxanes．Methods Thirty eight cases of advanced breast cancer pretreated with anthracyclines and／or taxanes were enrolled into this study，Gemcitabine 1 200mg／m iv，combined with leucovorin 200mg／ln iv，then 1 0 minules，intravenous bolus of 5一Fu 325mg／m fol- lowed by 48 hours infusion of 5一Fu 2．8 m2 using an ambulatory pump．2he regimen was given per 14 days．One cycle consisted of twice chemotherapy regimens．All enrolled patients received at least twO cycle of treatment． Results CR 2 cases、PR 1 4 cases、NC 1 3 cases；PD 9 cases an overall respons rate of 42．1％．The main side effect included grade III～1V leckopenia 1 8．4％，grade III thrombocytopenia 5．9％．Conclusion Gemcitabine plus 5-fluorouracil／leucovorin GLF regimen is effective for advanced breast cancer resistant to anthracycfines and／ or taxcines．