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综述:基因调控
Front. Electr. Electron. Eng. China 2008, 3(3): 251–259
DOI 10.1007/s11460-008-0066-7
REVIEW ARTICLE
Jin GU
Brief review: frontiers in the computational studies of gene
regulations
E Higher Education Press and Springer-Verlag 2008
Abstract Computational methods have greatly expanded them enter this promising field and have a comprehen-
our understanding of complex gene regulations in a systema- sive understanding of the frontiers on gene regulations.
tic view. The rapid progress in molecular biology and high- Three related sections are written to introduce the com-
throughput bio-techniques is providing new opportunities and putational studies of gene regulations.
challenges for the computational analysis of gene regulations. The ‘‘easiest’’ way to start the computational studies
about gene regulations would be the genome-wide predic-
Keywords computational biology, bioinformatics, gene tions of specific types of regulatory events or elements/
regulations, regulatory networks motifs* (the terminologies denoted by * will be shortly
explained in Appendix A). In recent years, many new reg-
ulatory mechanisms have been discovered, including
1 Introduction alternative splicing [5–7] and microRNAs (miRNAs)-
directed gene silencing [8–11]. Using biological experi-
Originally, gene regulations mean the regulations of gene ments to identify all these regulations is still time-consum-
expression (the transcription or translation of genes). ing and costly. By c
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