涡虫在研究药物成瘾机制中应用.pdf

# 292# 2009 40 4 # 综 述# * 1 1, v 2 卢慧甍 尹大川 徐 畅 ( 1 , , , 710072; 2, 710062) 药物成瘾危害人类健康并带来经济和社会问题, 而滥用药物所造成的身体损害身体依赖和 断综合征的治疗等问题的解决仍存在困难涡虫具有原始的中枢神经系统, 其神经递质系统与 哺乳类相似, 具有易观察可量化的 断反应, 具有易饲养低成本无伦理问题等优于哺乳类实验动 物的特点, 因而迅速成为新的神经药理学在体动物实验模型本文对涡虫的优点及其在药物成瘾 机制等方面的研究进展进行综述, 为药物成瘾机制及其治疗的研究提供新的思路 涡虫; 药物成瘾; 动物模型 Q42 1 1 Investigations of D rug Add iction M echan ism in P lanarians LU H ui-M eng , Y IN Da-Chuan , XU 2 1 Chang ( Faculty of Lfi e S ciences, N orthw estern P oly technical Univ ersity, K ey Laboratory f or Sp ace B iosci- 2 ence and B iotechnology, nstitute of Sp ecial Env ironm ental B iop hy sics, X ian 710072, China; College of Lfi e Sc iences, Shaanx iN orm al Univ ersity, X ian 710062, Ch ina) Abs tract D ug abuse ha m s people s health and lead to a se ies of econom ic, socia l and po lit ical p ob- lem s. H ow eve, the p ob lem s of physical dam age, physica l dependence and w ithd aw al synd om e caused by d ug abuse st ill ex ist. Plana ians have been a new anmi al expe mi enta lm odel in v ivo fo neu opha m a- co logy, because they possess a p mi it ive cent al ne vous system and neu ot ansm itte system s smi ila ly to m amm alians. In add ition, they have the advantage of convenience and low cost and no ethics p oblem s com pa ed w ith m amm alian m ode ls. The advantages of plana ian as expe mi enta l m ode l in v ivo and the p og ess of the investigations of d ug addict ion m echanism in plana